{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alexander KL"],"funding":["National Institute of Allergy and Infectious Diseases","Crohn&apos;s and Colitis Foundation of America","Kenneth Rainin Foundation","NIAID NIH HHS","Crohn's & Colitis Foundation","National Institutes of Health","U.S. Department of Veterans Affairs","CSRD VA"],"pagination":["522-535.e6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8489510"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["161(2)"],"pubmed_abstract":["<h4>Background and aims</h4>Crohn's disease and ulcerative colitis are characterized by dysregulated adaptive immune responses to the microbiota in genetically susceptible individuals, but the specificity of these responses remains largely undefined. Therefore, we developed a microbiota antigen microarray to characterize microbial antibody reactivity, particularly to human-derived microbiota flagellins, in inflammatory bowel disease.<h4>Methods</h4>Sera from healthy volunteers (n = 87) at the University of Alabama at Birmingham and from patients recruited from the Kirklin Clinic of University of Alabama at Birmingham Hospital, including patients with Crohn's disease (n = 152) and ulcerative colitis (n = 170), were individually probed against microbiota bacterial flagellins of both mouse an"],"journal":["Gastroenterology"],"pubmed_title":["Human Microbiota Flagellins Drive Adaptive Immune Responses in Crohn's Disease."],"pmcid":["PMC8489510"],"funding_grant_id":["32655","I01 CX001530","T32 AI007051","523929","CX0001530","AI007051","KRA000010"],"pubmed_authors":["Alexander KL","Reif M","Duck LW","Zhao Q","Rosenberg AF","Mannon PJ","Elson CO"],"additional_accession":[]},"is_claimable":false,"name":"Human Microbiota Flagellins Drive Adaptive Immune Responses in Crohn's Disease.","description":"<h4>Background and aims</h4>Crohn's disease and ulcerative colitis are characterized by dysregulated adaptive immune responses to the microbiota in genetically susceptible individuals, but the specificity of these responses remains largely undefined. Therefore, we developed a microbiota antigen microarray to characterize microbial antibody reactivity, particularly to human-derived microbiota flagellins, in inflammatory bowel disease.<h4>Methods</h4>Sera from healthy volunteers (n = 87) at the University of Alabama at Birmingham and from patients recruited from the Kirklin Clinic of University of Alabama at Birmingham Hospital, including patients with Crohn's disease (n = 152) and ulcerative colitis (n = 170), were individually probed against microbiota bacterial flagellins of both mouse an","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2026-05-08T11:29:45.291Z","creation":"2025-04-19T06:02:51.344Z"},"accession":"S-EPMC8489510","cross_references":{"pubmed":["33844987"],"doi":["10.1053/j.gastro.2021.03.064"]}}