biostudies-literatureChoi JHBoramae Medical CenterSeoul Metropolitan Government-Seoul National University221-225https://www.ebi.ac.uk/biostudies/studies/S-EPMC8490186biostudies-literatureUnknown14(3)<h4>Objective</h4>To assess nocturnal hypokinesia using the Korean version of the Nocturnal Hypokinesia Questionnaire (NHQ-K) in Parkinson's disease (PD) patients across disease stages.<h4>Methods</h4>We developed the NHQ-K and performed questionnaire-based interviews with 108 PD patients from three referral hospitals. Clinical associations of nocturnal hypokinesia and its impact on health-related quality of life (HRQoL) were also analyzed.<h4>Results</h4>The NHQ-K showed acceptable internal consistency (0.83) and interrater reliability (0.95). Nocturnal hypokinesia significantly affected HRQoL in PD patients at both the early and advanced stages (adjusted p < 0.001). Increased severity of nocturnal hypokinesia was associated with dyskinesias, off-period disability, apathy, and anxious mooJournal of movement disordersInvestigation of Nocturnal Hypokinesia and Health-Related Quality of Life in Parkinsonian Patients with the Korean Version of the Nocturnal Hypokinesia Questionnaire.PMC849018603-2018-8Shin CAhn TBKim JMJeon BKim HJYoo DChoi JHWoo KAIm JHLee JYfalseInvestigation of Nocturnal Hypokinesia and Health-Related Quality of Life in Parkinsonian Patients with the Korean Version of the Nocturnal Hypokinesia Questionnaire.<h4>Objective</h4>To assess nocturnal hypokinesia using the Korean version of the Nocturnal Hypokinesia Questionnaire (NHQ-K) in Parkinson's disease (PD) patients across disease stages.<h4>Methods</h4>We developed the NHQ-K and performed questionnaire-based interviews with 108 PD patients from three referral hospitals. Clinical associations of nocturnal hypokinesia and its impact on health-related quality of life (HRQoL) were also analyzed.<h4>Results</h4>The NHQ-K showed acceptable internal consistency (0.83) and interrater reliability (0.95). Nocturnal hypokinesia significantly affected HRQoL in PD patients at both the early and advanced stages (adjusted p < 0.001). Increased severity of nocturnal hypokinesia was associated with dyskinesias, off-period disability, apathy, and anxious moo2021-01-01T00:00:00Z2021 Sep2025-06-01T12:10:52.86Z2022-02-11T12:06:30.266ZS-EPMC84901863403043310.14802/jmd.20172