{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(38)"],"submitter":["Yuan Y"],"funding":["China Scholarship Council"],"pubmed_abstract":["Secondary amides are omnipresent structural motifs in peptides, natural products, pharmaceuticals, and agrochemicals. The copper-catalyzed enantioselective hydroaminocarbonylation of alkenes described in this study provides a direct and practical approach for the construction of α-chiral secondary amides. An electrophilic amine transfer reagent possessing a 4-(dimethylamino)benzoate group was the key to the success. This method also features broad functional group tolerance and proceeds under very mild conditions, affording a set of α-chiral secondary amides in high yields (up to 96% yield) with unprecedented levels of enantioselectivity (up to >99% ee). α,β-Unsaturated secondary amides can also be produced though the method by using alkynes as the substrate."],"journal":["Chemical science"],"pagination":["12676-12681"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8494041"],"repository":["biostudies-literature"],"pubmed_title":["Copper-catalyzed enantioselective carbonylation toward α-chiral secondary amides."],"pmcid":["PMC8494041"],"pubmed_authors":["Zhao F","Yuan Y","Wu XF"],"additional_accession":[]},"is_claimable":false,"name":"Copper-catalyzed enantioselective carbonylation toward α-chiral secondary amides.","description":"Secondary amides are omnipresent structural motifs in peptides, natural products, pharmaceuticals, and agrochemicals. The copper-catalyzed enantioselective hydroaminocarbonylation of alkenes described in this study provides a direct and practical approach for the construction of α-chiral secondary amides. An electrophilic amine transfer reagent possessing a 4-(dimethylamino)benzoate group was the key to the success. This method also features broad functional group tolerance and proceeds under very mild conditions, affording a set of α-chiral secondary amides in high yields (up to 96% yield) with unprecedented levels of enantioselectivity (up to >99% ee). α,β-Unsaturated secondary amides can also be produced though the method by using alkynes as the substrate.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-22T11:26:02.56Z","creation":"2025-04-06T00:00:41.69Z"},"accession":"S-EPMC8494041","cross_references":{"pubmed":["34703553"],"doi":["10.1039/d1sc04210f"]}}