biostudies-literatureUnknown12(38)Yuan YChina Scholarship CouncilSecondary amides are omnipresent structural motifs in peptides, natural products, pharmaceuticals, and agrochemicals. The copper-catalyzed enantioselective hydroaminocarbonylation of alkenes described in this study provides a direct and practical approach for the construction of α-chiral secondary amides. An electrophilic amine transfer reagent possessing a 4-(dimethylamino)benzoate group was the key to the success. This method also features broad functional group tolerance and proceeds under very mild conditions, affording a set of α-chiral secondary amides in high yields (up to 96% yield) with unprecedented levels of enantioselectivity (up to >99% ee). α,β-Unsaturated secondary amides can also be produced though the method by using alkynes as the substrate.Chemical science12676-12681https://www.ebi.ac.uk/biostudies/studies/S-EPMC8494041biostudies-literatureCopper-catalyzed enantioselective carbonylation toward α-chiral secondary amides.PMC8494041Zhao FYuan YWu XFfalseCopper-catalyzed enantioselective carbonylation toward α-chiral secondary amides.Secondary amides are omnipresent structural motifs in peptides, natural products, pharmaceuticals, and agrochemicals. The copper-catalyzed enantioselective hydroaminocarbonylation of alkenes described in this study provides a direct and practical approach for the construction of α-chiral secondary amides. An electrophilic amine transfer reagent possessing a 4-(dimethylamino)benzoate group was the key to the success. This method also features broad functional group tolerance and proceeds under very mild conditions, affording a set of α-chiral secondary amides in high yields (up to 96% yield) with unprecedented levels of enantioselectivity (up to >99% ee). α,β-Unsaturated secondary amides can also be produced though the method by using alkynes as the substrate.2021-01-01T00:00:00Z2021 Oct2025-04-22T11:26:02.56Z2025-04-06T00:00:41.69ZS-EPMC84940413470355310.1039/d1sc04210f