{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Lichtenberg C"],"funding":["U.S. Department of Energy","Vetenskapsrådet","ÅForsk","Oklahoma Humanities Council"],"pagination":["12763-12775"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8494045"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(38)"],"pubmed_abstract":["The molecular oxygen we breathe is produced from water-derived oxygen species bound to the Mn<sub>4</sub>CaO<sub>5</sub> cluster in photosystem II (PSII). Present research points to the central oxo-bridge O5 as the 'slow exchanging substrate water (W<sub>s</sub>)', while, in the S<sub>2</sub> state, the terminal water ligands W2 and W3 are both discussed as the 'fast exchanging substrate water (W<sub>f</sub>)'. A critical point for the assignment of W<sub>f</sub> is whether or not its exchange with bulk water is limited by barriers in the channels leading to the Mn<sub>4</sub>CaO<sub>5</sub> cluster. In this study, we measured the rates of H<sub>2</sub> <sup>16</sup>O/H<sub>2</sub> <sup>18</sup>O substrate water exchange in the S<sub>2</sub> and S<sub>3</sub> states of PSII core complexes "],"journal":["Chemical science"],"pubmed_title":["The exchange of the fast substrate water in the S<sub>2</sub> state of photosystem II is limited by diffusion of bulk water through channels - implications for the water oxidation mechanism."],"pmcid":["PMC8494045"],"funding_grant_id":["2016-05183","2020-03809","DE-SC0005291"],"pubmed_authors":["de Lichtenberg C","Chernev P","Messinger J","Debus RJ","Kim CJ"],"additional_accession":[]},"is_claimable":false,"name":"The exchange of the fast substrate water in the S<sub>2</sub> state of photosystem II is limited by diffusion of bulk water through channels - implications for the water oxidation mechanism.","description":"The molecular oxygen we breathe is produced from water-derived oxygen species bound to the Mn<sub>4</sub>CaO<sub>5</sub> cluster in photosystem II (PSII). Present research points to the central oxo-bridge O5 as the 'slow exchanging substrate water (W<sub>s</sub>)', while, in the S<sub>2</sub> state, the terminal water ligands W2 and W3 are both discussed as the 'fast exchanging substrate water (W<sub>f</sub>)'. A critical point for the assignment of W<sub>f</sub> is whether or not its exchange with bulk water is limited by barriers in the channels leading to the Mn<sub>4</sub>CaO<sub>5</sub> cluster. In this study, we measured the rates of H<sub>2</sub> <sup>16</sup>O/H<sub>2</sub> <sup>18</sup>O substrate water exchange in the S<sub>2</sub> and S<sub>3</sub> states of PSII core complexes ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-05-08T20:22:14.874Z","creation":"2025-02-19T00:27:53.599Z"},"accession":"S-EPMC8494045","cross_references":{"pubmed":["34703563"],"doi":["10.1039/d1sc02265b"]}}