{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ziffra RS"],"funding":["NIMH NIH HHS","NHGRI NIH HHS","NIH HHS","NIGMS NIH HHS"],"pagination":["205-213"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8494642"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["598(7879)"],"pubmed_abstract":["During mammalian development, differences in chromatin state coincide with cellular differentiation and reflect changes in the gene regulatory landscape<sup>1</sup>. In the developing brain, cell fate specification and topographic identity are important for defining cell identity<sup>2</sup> and confer selective vulnerabilities to neurodevelopmental disorders<sup>3</sup>. Here, to identify cell-type-specific chromatin accessibility patterns in the developing human brain, we used a single-cell assay for transposase accessibility by sequencing (scATAC-seq) in primary tissue samples from the human forebrain. We applied unbiased analyses to identify genomic loci that undergo extensive cell-type- and brain-region-specific changes in accessibility during neurogenesis, and an integrative analysis"],"journal":["Nature"],"pubmed_title":["Single-cell epigenomics reveals mechanisms of human cortical development."],"pmcid":["PMC8494642"],"funding_grant_id":["1K99 MH117165","5U41 HG002371-19","U41 HG002371","RF1 MH132662","K99 MH117165","U24 HG002371","U01 MH114825","T32 GM007175","R01 MH109907","U01 MH116438","U01 MH115747","R01 MH125516","R01 MH123178","R01 MH101221","RF1 MH121268"],"pubmed_authors":["Ziffra RS","Nowakowski TJ","Haeussler M","Kim CN","Przytycki PF","Wilfert A","Turner TN","Pollard KS","Keough KC","Shin D","Ross JM","Kreimer A","Bogdanoff D","Casella AM","Eichler EE","Ahituv N","Ament SA"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell epigenomics reveals mechanisms of human cortical development.","description":"During mammalian development, differences in chromatin state coincide with cellular differentiation and reflect changes in the gene regulatory landscape<sup>1</sup>. In the developing brain, cell fate specification and topographic identity are important for defining cell identity<sup>2</sup> and confer selective vulnerabilities to neurodevelopmental disorders<sup>3</sup>. Here, to identify cell-type-specific chromatin accessibility patterns in the developing human brain, we used a single-cell assay for transposase accessibility by sequencing (scATAC-seq) in primary tissue samples from the human forebrain. We applied unbiased analyses to identify genomic loci that undergo extensive cell-type- and brain-region-specific changes in accessibility during neurogenesis, and an integrative analysis","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-05-07T22:25:24.501Z","creation":"2025-04-19T08:25:16.537Z"},"accession":"S-EPMC8494642","cross_references":{"pubmed":["34616060"],"doi":["10.1038/s41586-021-03209-8"]}}