{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Labbe K"],"funding":["National Cancer Institute","National Institutes of Health","Canadian Institutes of Health Research"],"pagination":["e202103122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8496048"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["220(11)"],"pubmed_abstract":["Mitochondrial function is integrated with cellular status through the regulation of opposing mitochondrial fusion and division events. Here we uncover a link between mitochondrial dynamics and lipid metabolism by examining the cellular role of mitochondrial carrier homologue 2 (MTCH2). MTCH2 is a modified outer mitochondrial membrane carrier protein implicated in intrinsic cell death and in the in vivo regulation of fatty acid metabolism. Our data indicate that MTCH2 is a selective effector of starvation-induced mitochondrial hyperfusion, a cytoprotective response to nutrient deprivation. We find that MTCH2 stimulates mitochondrial fusion in a manner dependent on the bioactive lipogenesis intermediate lysophosphatidic acid. We propose that MTCH2 monitors flux through the lipogenesis pathwa"],"journal":["The Journal of cell biology"],"pubmed_title":["The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis."],"pmcid":["PMC8496048"],"funding_grant_id":["1S10RR024543-01","P30CA093373","R01GM126081","R37GM097432","S10OD021801"],"pubmed_authors":["Lerner C","Le Vasseur M","Labbe K","Nunnari J","Mookerjee S","Gibbs E"],"additional_accession":[]},"is_claimable":false,"name":"The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis.","description":"Mitochondrial function is integrated with cellular status through the regulation of opposing mitochondrial fusion and division events. Here we uncover a link between mitochondrial dynamics and lipid metabolism by examining the cellular role of mitochondrial carrier homologue 2 (MTCH2). MTCH2 is a modified outer mitochondrial membrane carrier protein implicated in intrinsic cell death and in the in vivo regulation of fatty acid metabolism. Our data indicate that MTCH2 is a selective effector of starvation-induced mitochondrial hyperfusion, a cytoprotective response to nutrient deprivation. We find that MTCH2 stimulates mitochondrial fusion in a manner dependent on the bioactive lipogenesis intermediate lysophosphatidic acid. We propose that MTCH2 monitors flux through the lipogenesis pathwa","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-05T14:05:35.217Z","creation":"2025-04-05T14:05:35.217Z"},"accession":"S-EPMC8496048","cross_references":{"pubmed":["34586346"],"doi":["10.1083/jcb.202103122"]}}