{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hinman JD"],"funding":["National Institute for Nanotechnology","COST","Landes-Offensive zur Entwicklung Wissenschaftlichökonomischer Exzellenz","Deutsche Forschungsgemeinschaft","Universtätsklinikum Giessen Marburg","National Multiple Sclerosis Society","Ural Federal University","NINDS NIH HHS","University of California, Los Angeles","German Center for Lung Research"],"pagination":["103-118"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8496370"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(1)"],"pubmed_abstract":["Oligodendrocytes exist in a heterogenous state and are implicated in multiple neuropsychiatric diseases including dementia. Cortical oligodendrocytes are a glial population uniquely positioned to play a key role in neurodegeneration by synchronizing circuit connectivity but molecular pathways specific to this role are lacking. We utilized oligodendrocyte-specific translating ribosome affinity purification and RNA-seq (TRAP-seq) to transcriptionally profile adult mature oligodendrocytes from different regions of the central nervous system. Weighted gene co-expression network analysis reveals distinct region-specific gene networks. Two of these mature myelinating oligodendrocyte gene networks uniquely define cortical oligodendrocytes and differentially regulate cortical myelination (M8) and "],"journal":["Human molecular genetics"],"pubmed_title":["miR-142-3p regulates cortical oligodendrocyte gene co-expression networks associated with tauopathy."],"pmcid":["PMC8496370"],"funding_grant_id":["CRC1213","PP1892","DZL","R01 NS082094","K08 NS083740","BE4443/4-1","BE4443/6-1","BM1201"],"pubmed_authors":["Kushner SA","Kim D","Ghanbari M","Bellusci S","Kawaguchi R","Chen C","Fogel BL","Coppola G","Abraham CR","Ngo KJ","Hernandez I","Kosik KS","Ikram MA","Hinman JD","Goth K"],"additional_accession":[]},"is_claimable":false,"name":"miR-142-3p regulates cortical oligodendrocyte gene co-expression networks associated with tauopathy.","description":"Oligodendrocytes exist in a heterogenous state and are implicated in multiple neuropsychiatric diseases including dementia. Cortical oligodendrocytes are a glial population uniquely positioned to play a key role in neurodegeneration by synchronizing circuit connectivity but molecular pathways specific to this role are lacking. We utilized oligodendrocyte-specific translating ribosome affinity purification and RNA-seq (TRAP-seq) to transcriptionally profile adult mature oligodendrocytes from different regions of the central nervous system. Weighted gene co-expression network analysis reveals distinct region-specific gene networks. Two of these mature myelinating oligodendrocyte gene networks uniquely define cortical oligodendrocytes and differentially regulate cortical myelination (M8) and ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-05T14:05:39.557Z","creation":"2025-04-05T14:05:39.557Z"},"accession":"S-EPMC8496370","cross_references":{"pubmed":["33555315"],"doi":["10.1093/hmg/ddaa252"]}}