biostudies-literatureKusakabe MScientific Research CScientific Research BEarly-Career Scientists from the Japan Society for the Promotion of ScienceNVIDIA Corporation provided support to Jason Lin in the form of hardware devicesGrant-in-Aids for Scientific Research on Innovative AreasThe SAPOIN strategic elevation of basic scientific research initiative from the Ministry of Economy, Trade and Industry of Japane12247https://www.ebi.ac.uk/biostudies/studies/S-EPMC8496461biostudies-literatureUnknown9Despite the benefit of early cancer screening, Japan has one of the lowest cancer screening rates among developed countries, possibly due to there being a lack of "a good test" that can provide sufficient levels of test sensitivity and accuracy without a large price tag. As a number of essential and trace elements have been intimately connected to the oncogenesis of cancer, Metallobalance, a recent development in elemental analysis utilizing the technique of inductively coupled plasma mass spectrometry has been developed and tested as a robust method for arrayed cancer risk screening. We have conducted case-control epidemiological studies in the prefecture of Chiba, in the Greater Tokyo Area, and sought to determine both Metallobalance screening's effectiveness for predicting pan-cancer ouPeerJElemental analysis by Metallobalance provides a complementary support layer over existing blood biochemistry panel-based cancer risk assessment.PMC8496461221S0001JP17K15047JP20H0354021K1507216H06277JP20K10440Nagase HKusakabe MNakamura YSato MLin JMikami HfalseElemental analysis by Metallobalance provides a complementary support layer over existing blood biochemistry panel-based cancer risk assessment.Despite the benefit of early cancer screening, Japan has one of the lowest cancer screening rates among developed countries, possibly due to there being a lack of "a good test" that can provide sufficient levels of test sensitivity and accuracy without a large price tag. As a number of essential and trace elements have been intimately connected to the oncogenesis of cancer, Metallobalance, a recent development in elemental analysis utilizing the technique of inductively coupled plasma mass spectrometry has been developed and tested as a robust method for arrayed cancer risk screening. We have conducted case-control epidemiological studies in the prefecture of Chiba, in the Greater Tokyo Area, and sought to determine both Metallobalance screening's effectiveness for predicting pan-cancer ou2021-01-01T00:00:00Z20212025-06-01T02:38:29.789Z2025-06-01T02:38:29.789ZS-EPMC84964613470793510.7717/peerj.12247