{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["141(11)"],"submitter":["Daniels AM"],"funding":["Maastricht University","VieCuri Medisch Centrum"],"pubmed_abstract":["<h4>Introduction</h4>The aim of this study was to investigate the associations of patient characteristics, bone mineral density (BMD), bone microarchitecture and calculated bone strength with secondary displacement of a DRF based on radiographic alignment parameters.<h4>Materials and methods</h4>Dorsal angulation, radial inclination and ulnar variance were assessed on conventional radiographs of a cohort of 251 patients, 38 men and 213 women, to determine the anatomic position of the DRF at presentation (primary position) and during follow-up. Secondary fracture displacement was assessed in the non-operatively treated patients (N = 154) with an acceptable position, preceded (N = 97) or not preceded (N = 57) by primary reduction (baseline position). Additionally, bone microarchitecture and calculated bone strength at the contralateral distal radius and tibia were assessed by HR-pQCT in a subset of, respectively, 63 and 71 patients.<h4>Outcome</h4>Characteristics of patients with and without secondary fracture displacement did not differ. In the model with adjustment for primary reduction [OR 22.00 (2.27-212.86), p = 0.008], total [OR 0.16 (95% CI 0.04-0.68), p = 0.013] and cortical [OR 0.19 (95% CI 0.05-0.80], p = 0.024] volumetric BMD (vBMD) and cortical thickness [OR 0.13 (95% CI 0.02-0.74), p = 0.021] at the distal radius were associated with secondary DRF displacement. No associations were found for other patient characteristics, such as age gender, BMD or prevalent vertebral fractures.<h4>Conclusions</h4>In conclusion, our study indicates that besides primary reduction, cortical bone quality may be important for the risk of secondary displacement of DRFs."],"journal":["Archives of orthopaedic and trauma surgery"],"pagination":["1909-1918"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8497288"],"repository":["biostudies-literature"],"pubmed_title":["Association of secondary displacement of distal radius fractures with cortical bone quality at the distal radius."],"pmcid":["PMC8497288"],"pubmed_authors":["Janzing HMJ","Wyers CE","Geusens PPMM","Van den Bergh JP","Daniels AM","Poeze M","Van der Velde RY","Kaarsemaker S","van Rietbergen B","Vranken L"],"additional_accession":[]},"is_claimable":false,"name":"Association of secondary displacement of distal radius fractures with cortical bone quality at the distal radius.","description":"<h4>Introduction</h4>The aim of this study was to investigate the associations of patient characteristics, bone mineral density (BMD), bone microarchitecture and calculated bone strength with secondary displacement of a DRF based on radiographic alignment parameters.<h4>Materials and methods</h4>Dorsal angulation, radial inclination and ulnar variance were assessed on conventional radiographs of a cohort of 251 patients, 38 men and 213 women, to determine the anatomic position of the DRF at presentation (primary position) and during follow-up. Secondary fracture displacement was assessed in the non-operatively treated patients (N = 154) with an acceptable position, preceded (N = 97) or not preceded (N = 57) by primary reduction (baseline position). Additionally, bone microarchitecture and calculated bone strength at the contralateral distal radius and tibia were assessed by HR-pQCT in a subset of, respectively, 63 and 71 patients.<h4>Outcome</h4>Characteristics of patients with and without secondary fracture displacement did not differ. In the model with adjustment for primary reduction [OR 22.00 (2.27-212.86), p = 0.008], total [OR 0.16 (95% CI 0.04-0.68), p = 0.013] and cortical [OR 0.19 (95% CI 0.05-0.80], p = 0.024] volumetric BMD (vBMD) and cortical thickness [OR 0.13 (95% CI 0.02-0.74), p = 0.021] at the distal radius were associated with secondary DRF displacement. No associations were found for other patient characteristics, such as age gender, BMD or prevalent vertebral fractures.<h4>Conclusions</h4>In conclusion, our study indicates that besides primary reduction, cortical bone quality may be important for the risk of secondary displacement of DRFs.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-05-18T12:31:28.381Z","creation":"2025-05-18T12:31:28.381Z"},"accession":"S-EPMC8497288","cross_references":{"pubmed":["33128608"],"doi":["10.1007/s00402-020-03658-2"]}}