biostudies-literatureKim MSChonnam National University132-139https://www.ebi.ac.uk/biostudies/studies/S-EPMC8498686biostudies-literatureUnknown9(3)<h4>Purpose</h4>The aim of this study was to investigate the effect of androgen deprivation therapy (ADT) on the health-related quality of life (HRQOL) of patients with prostate cancer (PC) and compare the changes in the HRQOL between ADT alone and ADT plus intensity-modulated radiation therapy (IMRT).<h4>Materials and methods</h4>Patients with PC were prospectively recruited between October 2018 and April 2020. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire and the PC-specific module (PR25) were administered before ADT (baseline) and at 3, 6, and 12 months after ADT. All patients received subcutaneous injections of 45 mg leuprolide acetate at 6-month intervals for 12 months.<h4>Results</h4>Fifty-five of the 71 patients (77.5%) completed the 12Prostate internationalEffects of leuprolide acetate on the quality of life of patients with prostate cancer: A prospective longitudinal cohort study.PMC8498686HCRI 19017Kim MSJung SIChang Hwang EKwon DChung HSfalseEffects of leuprolide acetate on the quality of life of patients with prostate cancer: A prospective longitudinal cohort study.<h4>Purpose</h4>The aim of this study was to investigate the effect of androgen deprivation therapy (ADT) on the health-related quality of life (HRQOL) of patients with prostate cancer (PC) and compare the changes in the HRQOL between ADT alone and ADT plus intensity-modulated radiation therapy (IMRT).<h4>Materials and methods</h4>Patients with PC were prospectively recruited between October 2018 and April 2020. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire and the PC-specific module (PR25) were administered before ADT (baseline) and at 3, 6, and 12 months after ADT. All patients received subcutaneous injections of 45 mg leuprolide acetate at 6-month intervals for 12 months.<h4>Results</h4>Fifty-five of the 71 patients (77.5%) completed the 122021-01-01T00:00:00Z2021 Sep2025-04-19T15:09:11.741Z2025-04-19T15:09:11.741ZS-EPMC84986863469258510.1016/j.prnil.2020.11.001