biostudies-literatureLavikainen LITerveyden Tutkimuksen ToimikuntaHelsingin ja Uudenmaan SairaanhoitopiiriSigrid Juséliuksen Säätiö264https://www.ebi.ac.uk/biostudies/studies/S-EPMC8499502biostudies-literatureUnknown10(1)<h4>Background</h4>Venous thromboembolism (VTE) and bleeding are serious and potentially fatal complications of surgical procedures. Pharmacological thromboprophylaxis decreases the risk of VTE but increases the risk of major post-operative bleeding. The decision to use pharmacologic prophylaxis therefore represents a trade-off that critically depends on the incidence of VTE and bleeding in the absence of prophylaxis. These baseline risks vary widely between procedures, but their magnitude is uncertain. Systematic reviews addressing baseline risks are scarce, needed, and require innovations in methodology. Indeed, systematic summaries of these baseline risk estimates exist neither in general nor gynecologic surgery. We will fill this knowledge gap by performing a series of systematic revieSystematic reviewsSystematic reviews of observational studies of Risk of Thrombosis and Bleeding in General and Gynecologic Surgery (ROTBIGGS): introduction and methodology.PMC8499502309387TYH2020248TYH2019321Luomaranta ALLampela HCardenas JLKalliala IEJKaranicolas PJHuang LMattila AKKhamani NTahtinen RMKorhonen TPandanaboyana SBeilmann-Lehtonen IPourjamal NGarcia-Perdomo HAKivela AJVernooij RWMCouban RJJoronen KMAaltonen RLWang YBlanker MHOksjoki SMSingh TAro KMGe FZYao LLavikainen LIHaukka JSallinen VJAhopelto KNysten CXiao YCraigie SNykanen TPCartwright RKilpelainen TPKarjalainen PKNajafabadi BTRatnayake CBBTikkinen KAOLee YGalambosi PJGomaa HAIzett-Kay MLRaudasoja ARGuyatt GHfalseSystematic reviews of observational studies of Risk of Thrombosis and Bleeding in General and Gynecologic Surgery (ROTBIGGS): introduction and methodology.<h4>Background</h4>Venous thromboembolism (VTE) and bleeding are serious and potentially fatal complications of surgical procedures. Pharmacological thromboprophylaxis decreases the risk of VTE but increases the risk of major post-operative bleeding. The decision to use pharmacologic prophylaxis therefore represents a trade-off that critically depends on the incidence of VTE and bleeding in the absence of prophylaxis. These baseline risks vary widely between procedures, but their magnitude is uncertain. Systematic reviews addressing baseline risks are scarce, needed, and require innovations in methodology. Indeed, systematic summaries of these baseline risk estimates exist neither in general nor gynecologic surgery. We will fill this knowledge gap by performing a series of systematic revie2021-01-01T00:00:00Z2021 Oct2025-05-31T23:33:33.608Z2022-02-11T12:00:24.696ZS-EPMC84995023462509210.1186/s13643-021-01814-2