{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["159"],"submitter":["Haeusler GM"],"pubmed_abstract":["<h4>Purpose</h4>There are limited data on SARS-CoV-2 (COVID-19) infection in children with cancer or after haematopoietic stem cell transplant (HSCT). We describe the severity and outcomes of SARS-COV-2 in these patients and identify factors associated with severe disease.<h4>Methods</h4>This was a multinational, observational study of children (aged <19 years) with cancer or HSCT and SARS-CoV-2 confirmed by polymerase chain reaction. COVID-19 was classified as asymptomatic, mild, moderate, severe or critical (≥1 organ support). Exact polytomous regression was used to determine the relationship between clinical variables and disease severity.<h4>Results</h4>One hundred and thirty-one patients with COVID-19 across 10 countries were identified (median age 8 years). Seventy-eight (60%) had le"],"journal":["European journal of cancer (Oxford, England : 1990)"],"pagination":["78-86"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8501219"],"repository":["biostudies-literature"],"pubmed_title":["SARS-CoV-2 in children with cancer or after haematopoietic stem cell transplant: An analysis of 131 patients."],"pmcid":["PMC8501219"],"pubmed_authors":["Ammann RA","Attarbaschi A","Sung L","Groll AH","Gilli F","Wegehaupt O","Speckmann C","Carlesse F","Solopova G","Averbuch D","Agyeman PKA","Lehrnbecher T","Phillips B","Haeusler GM","Castagnola E"],"additional_accession":[]},"is_claimable":false,"name":"SARS-CoV-2 in children with cancer or after haematopoietic stem cell transplant: An analysis of 131 patients.","description":"<h4>Purpose</h4>There are limited data on SARS-CoV-2 (COVID-19) infection in children with cancer or after haematopoietic stem cell transplant (HSCT). We describe the severity and outcomes of SARS-COV-2 in these patients and identify factors associated with severe disease.<h4>Methods</h4>This was a multinational, observational study of children (aged <19 years) with cancer or HSCT and SARS-CoV-2 confirmed by polymerase chain reaction. COVID-19 was classified as asymptomatic, mild, moderate, severe or critical (≥1 organ support). Exact polytomous regression was used to determine the relationship between clinical variables and disease severity.<h4>Results</h4>One hundred and thirty-one patients with COVID-19 across 10 countries were identified (median age 8 years). Seventy-eight (60%) had le","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-20T00:26:57.845Z","creation":"2022-02-11T13:25:03.633Z"},"accession":"S-EPMC8501219","cross_references":{"pubmed":["34736044"],"doi":["10.1016/j.ejca.2021.09.027"]}}