biostudies-literatureUnknown159Haeusler GM<h4>Purpose</h4>There are limited data on SARS-CoV-2 (COVID-19) infection in children with cancer or after haematopoietic stem cell transplant (HSCT). We describe the severity and outcomes of SARS-COV-2 in these patients and identify factors associated with severe disease.<h4>Methods</h4>This was a multinational, observational study of children (aged <19 years) with cancer or HSCT and SARS-CoV-2 confirmed by polymerase chain reaction. COVID-19 was classified as asymptomatic, mild, moderate, severe or critical (≥1 organ support). Exact polytomous regression was used to determine the relationship between clinical variables and disease severity.<h4>Results</h4>One hundred and thirty-one patients with COVID-19 across 10 countries were identified (median age 8 years). Seventy-eight (60%) had leEuropean journal of cancer (Oxford, England : 1990)78-86https://www.ebi.ac.uk/biostudies/studies/S-EPMC8501219biostudies-literatureSARS-CoV-2 in children with cancer or after haematopoietic stem cell transplant: An analysis of 131 patients.PMC8501219Ammann RAAttarbaschi ASung LGroll AHGilli FWegehaupt OSpeckmann CCarlesse FSolopova GAverbuch DAgyeman PKALehrnbecher TPhillips BHaeusler GMCastagnola EfalseSARS-CoV-2 in children with cancer or after haematopoietic stem cell transplant: An analysis of 131 patients.<h4>Purpose</h4>There are limited data on SARS-CoV-2 (COVID-19) infection in children with cancer or after haematopoietic stem cell transplant (HSCT). We describe the severity and outcomes of SARS-COV-2 in these patients and identify factors associated with severe disease.<h4>Methods</h4>This was a multinational, observational study of children (aged <19 years) with cancer or HSCT and SARS-CoV-2 confirmed by polymerase chain reaction. COVID-19 was classified as asymptomatic, mild, moderate, severe or critical (≥1 organ support). Exact polytomous regression was used to determine the relationship between clinical variables and disease severity.<h4>Results</h4>One hundred and thirty-one patients with COVID-19 across 10 countries were identified (median age 8 years). Seventy-eight (60%) had le2021-01-01T00:00:00Z2021 Dec2025-04-20T00:26:57.845Z2022-02-11T13:25:03.633ZS-EPMC85012193473604410.1016/j.ejca.2021.09.027