{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lynch EM"],"funding":["HHS | NIH | NIH Office of the Director","HHS | NIH | National Institute of General Medical Sciences","NIAID NIH HHS","HHS | NIH | National Institute of Allergy and Infectious Diseases","NIGMS NIH HHS","NIH HHS"],"pagination":["e2107968118"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8501788"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["118(40)"],"pubmed_abstract":["Cytidine triphosphate synthase 1 (CTPS1) is necessary for an effective immune response, as revealed by severe immunodeficiency in CTPS1-deficient individuals [E. Martin <i>et al</i>], [<i>Nature</i>] [510], [288-292] ([2014]). CTPS1 expression is up-regulated in activated lymphocytes to expand CTP pools [E. Martin <i>et al</i>], [<i>Nature</i>] [510], [288-292] ([2014]), satisfying increased demand for nucleic acid and lipid synthesis [L. D. Fairbanks, M. Bofill, K. Ruckemann, H. A. Simmonds], [<i>J. Biol. Chem.</i> ] [270], [29682-29689] ([1995]). Demand for CTP in other tissues is met by the CTPS2 isoform and nucleoside salvage pathways [E. Martin <i>et al</i>], [<i>Nature</i>] [510], [288-292] ([2014]). Selective inhibition of the proliferative CTPS1 isoform is therefore desirable in th"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Structural basis for isoform-specific inhibition of human CTPS1."],"pmcid":["PMC8501788"],"funding_grant_id":["GM007270","R01 AI153048","S10 OD023476","GM118396","R01 GM118396","S10OD032290","AI153048","T32 GM007270"],"pubmed_authors":["Lynch EM","Hansen JM","Quispe JD","Kaila N","Albanese S","McElwee JJ","Kennedy MA","Kreutter KD","Kollman JM","Verras A","Borrelli K","DiMattia MA","Toms AV","van Zundert GCP"],"additional_accession":[]},"is_claimable":false,"name":"Structural basis for isoform-specific inhibition of human CTPS1.","description":"Cytidine triphosphate synthase 1 (CTPS1) is necessary for an effective immune response, as revealed by severe immunodeficiency in CTPS1-deficient individuals [E. Martin <i>et al</i>], [<i>Nature</i>] [510], [288-292] ([2014]). CTPS1 expression is up-regulated in activated lymphocytes to expand CTP pools [E. Martin <i>et al</i>], [<i>Nature</i>] [510], [288-292] ([2014]), satisfying increased demand for nucleic acid and lipid synthesis [L. D. Fairbanks, M. Bofill, K. Ruckemann, H. A. Simmonds], [<i>J. Biol. Chem.</i> ] [270], [29682-29689] ([1995]). Demand for CTP in other tissues is met by the CTPS2 isoform and nucleoside salvage pathways [E. Martin <i>et al</i>], [<i>Nature</i>] [510], [288-292] ([2014]). Selective inhibition of the proliferative CTPS1 isoform is therefore desirable in th","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-06-12T08:59:44.492Z","creation":"2025-02-19T00:03:22.107Z"},"accession":"S-EPMC8501788","cross_references":{"pubmed":["34583994"],"doi":["10.1073/pnas.2107968118"]}}