{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Maziero MP"],"funding":["NIBIB NIH HHS","Fundacao de Amparo a Pesquisa do Estado de Sao Paulo","National Institutes of Health"],"pagination":["983-991"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8502196"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(10)"],"pubmed_abstract":["<h4>Background</h4>While previous studies have implicated white matter (WM) as a core pathology of obsessive-compulsive disorder (OCD), the underlying neurobiological processes remain elusive. This study used free-water (FW) imaging derived from diffusion magnetic resonance imaging to identify cellular and extracellular WM abnormalities in patients with OCD compared with control subjects. Next, we investigated the association between diffusion measures and clinical variables in patients.<h4>Methods</h4>We collected diffusion-weighted magnetic resonance imaging and clinical data from 83 patients with OCD (56 women/27 men, age 37.7 ± 10.6 years) and 52 control subjects (27 women/25 men, age 32.8 ± 11.5 years). Fractional anisotropy (FA), FA of cellular tissue, and extracellular FW maps were "],"journal":["Biological psychiatry. Cognitive neuroscience and neuroimaging"],"pubmed_title":["Cellular and Extracellular White Matter Abnormalities in Obsessive-Compulsive Disorder: A Diffusion Magnetic Resonance Imaging Study."],"pmcid":["PMC8502196"],"funding_grant_id":["P41 EB015902"],"pubmed_authors":["Tanamatis TW","Pasternak O","Shavitt RG","Goldenberg JE","Cappi C","Lopes AC","Diniz JB","Otaduy MCG","de Melo Felipe da Silva R","Maziero MP","Hoexter MQ","Cho KIK","da Graca Morais Martin M","Seitz-Holland J","Batistuzzo MC","Miguel EC","Alice de Mathis M"],"additional_accession":[]},"is_claimable":false,"name":"Cellular and Extracellular White Matter Abnormalities in Obsessive-Compulsive Disorder: A Diffusion Magnetic Resonance Imaging Study.","description":"<h4>Background</h4>While previous studies have implicated white matter (WM) as a core pathology of obsessive-compulsive disorder (OCD), the underlying neurobiological processes remain elusive. This study used free-water (FW) imaging derived from diffusion magnetic resonance imaging to identify cellular and extracellular WM abnormalities in patients with OCD compared with control subjects. Next, we investigated the association between diffusion measures and clinical variables in patients.<h4>Methods</h4>We collected diffusion-weighted magnetic resonance imaging and clinical data from 83 patients with OCD (56 women/27 men, age 37.7 ± 10.6 years) and 52 control subjects (27 women/25 men, age 32.8 ± 11.5 years). Fractional anisotropy (FA), FA of cellular tissue, and extracellular FW maps were ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-04T10:27:47.119Z","creation":"2025-02-19T01:21:52.076Z"},"accession":"S-EPMC8502196","cross_references":{"pubmed":["33862255"],"doi":["10.1016/j.bpsc.2021.04.001"]}}