{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23"],"submitter":["Zheng B"],"pubmed_abstract":["Long non-coding RNAs (lncRNAs) have been identified as critical contributors in tumor progression for many types of cancer. However, their functions in gallbladder cancer (GBC) have not been systematically clarified. In this study, the clinical significance, biological function, and underlying mechanism of lncRNA <i>RP11-147L13.8</i> in GBC were investigated. The quantitative real-time PCR result indicated that lncRNA <i>RP11-147L13.8</i> was found to be recurrently downregulated in GBC tumor samples. Kaplan-Meier analysis revealed that decreased lncRNA <i>RP11-147L13.8</i> expression level was associated with poor survival of GBC patients (p = 0.025). Then, both <i>in vitro</i> and <i>in vivo</i> experiments elucidated that the overexpression of lncRNA <i>RP11-147L13.8</i> suppressed the "],"journal":["Molecular therapy oncolytics"],"pagination":["124-137"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8507201"],"repository":["biostudies-literature"],"pubmed_title":["lncRNA <i>RP11-147L13.8</i> suppresses metastasis and chemo-resistance by modulating the phosphorylation of c-Jun protein in GBC."],"pmcid":["PMC8507201"],"pubmed_authors":["Liu H","Zhang D","Fan K","Ni X","Zheng B","Gao Z","Suo T","Shen S","Sun W","Wan W","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"lncRNA <i>RP11-147L13.8</i> suppresses metastasis and chemo-resistance by modulating the phosphorylation of c-Jun protein in GBC.","description":"Long non-coding RNAs (lncRNAs) have been identified as critical contributors in tumor progression for many types of cancer. However, their functions in gallbladder cancer (GBC) have not been systematically clarified. In this study, the clinical significance, biological function, and underlying mechanism of lncRNA <i>RP11-147L13.8</i> in GBC were investigated. The quantitative real-time PCR result indicated that lncRNA <i>RP11-147L13.8</i> was found to be recurrently downregulated in GBC tumor samples. Kaplan-Meier analysis revealed that decreased lncRNA <i>RP11-147L13.8</i> expression level was associated with poor survival of GBC patients (p = 0.025). Then, both <i>in vitro</i> and <i>in vivo</i> experiments elucidated that the overexpression of lncRNA <i>RP11-147L13.8</i> suppressed the ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-21T22:01:32.638Z","creation":"2022-02-11T13:44:48.534Z"},"accession":"S-EPMC8507201","cross_references":{"pubmed":["34703881"],"doi":["10.1016/j.omto.2021.08.016"]}}