biostudies-literatureSong MANational Cancer InstituteNCI NIH HHS188https://www.ebi.ac.uk/biostudies/studies/S-EPMC8507376biostudies-literatureUnknown13(1)<h4>Background</h4>Racial/ethnic disparities in health reflect a combination of genetic and environmental causes, and DNA methylation may be an important mediator. We compared in an exploratory manner the blood DNA methylome of Japanese Americans (JPA) versus European Americans (EUA).<h4>Methods</h4>Genome-wide buffy coat DNA methylation was profiled among healthy Multiethnic Cohort participant women who were Japanese (JPA; n = 30) or European (EUA; n = 28) Americans aged 60-65. Differentially methylated CpGs by race/ethnicity (DM-CpGs) were identified by linear regression (Bonferroni-corrected P < 0.1) and analyzed in relation to corresponding gene expression, a priori selected single nucleotide polymorphisms (SNPs), and blood biomarkers of inflammation and metabolism using Pearson or SpeClinical epigeneticsRace/ethnicity-associated blood DNA methylation differences between Japanese and European American women: an exploratory study.PMC8507376P30 CA0160583U01CA164973-09S1U01 CA164973P01 CA168530P30 CA071789Wilkens LRChang LSong MASeffernick AELim UArcher KJPeplowska KMori KMPark SYErnst TTiirikainen MLe Marchand LfalseRace/ethnicity-associated blood DNA methylation differences between Japanese and European American women: an exploratory study.<h4>Background</h4>Racial/ethnic disparities in health reflect a combination of genetic and environmental causes, and DNA methylation may be an important mediator. We compared in an exploratory manner the blood DNA methylome of Japanese Americans (JPA) versus European Americans (EUA).<h4>Methods</h4>Genome-wide buffy coat DNA methylation was profiled among healthy Multiethnic Cohort participant women who were Japanese (JPA; n = 30) or European (EUA; n = 28) Americans aged 60-65. Differentially methylated CpGs by race/ethnicity (DM-CpGs) were identified by linear regression (Bonferroni-corrected P < 0.1) and analyzed in relation to corresponding gene expression, a priori selected single nucleotide polymorphisms (SNPs), and blood biomarkers of inflammation and metabolism using Pearson or Spe2021-01-01T00:00:00Z2021 Oct2026-05-03T03:19:34.569Z2024-11-07T02:59:21.445ZS-EPMC85073763463516810.1186/s13148-021-01171-w