biostudies-literatureUnknown72Shen L<h4>Background</h4>Schizophrenia (SCZ) is a severe psychiatric disorder that affects approximately 0.75% of the global population. Both genetic and environmental factors contribute to development of SCZ. SCZ tends to run in family while both genetic and environmental factor contribute to its etiology. Much evidence suggested that alterations in DNA methylations occurred in SCZ patients.<h4>Methods</h4>To investigate potential inheritable pattern of DNA methylation in SCZ family, we performed a genome-wide analysis of DNA methylation of peripheral blood samples from 106 Chinese SCZ family trios. Genome-wide DNA methylations were quantified by Agilent 1 × 244 k Human Methylation Microarray.<h4>Findings</h4>In this study, we proposed a loci inheritance frequency model that allows characterizaEBioMedicine103609https://www.ebi.ac.uk/biostudies/studies/S-EPMC8511801biostudies-literatureGenome-wide analysis of DNA methylation in 106 schizophrenia family trios in Han Chinese.PMC8511801Shen LWeng STai SHuai CLv XTan JLu YHuang HChen LZhang NCai LHe LSun YLi LYang CLi MWu HShi YQin SWan CZhang YWang TMa JWu XfalseGenome-wide analysis of DNA methylation in 106 schizophrenia family trios in Han Chinese.<h4>Background</h4>Schizophrenia (SCZ) is a severe psychiatric disorder that affects approximately 0.75% of the global population. Both genetic and environmental factors contribute to development of SCZ. SCZ tends to run in family while both genetic and environmental factor contribute to its etiology. Much evidence suggested that alterations in DNA methylations occurred in SCZ patients.<h4>Methods</h4>To investigate potential inheritable pattern of DNA methylation in SCZ family, we performed a genome-wide analysis of DNA methylation of peripheral blood samples from 106 Chinese SCZ family trios. Genome-wide DNA methylations were quantified by Agilent 1 × 244 k Human Methylation Microarray.<h4>Findings</h4>In this study, we proposed a loci inheritance frequency model that allows characteriza2021-01-01T00:00:00Z2021 Oct2025-04-04T10:21:38.331Z2025-04-04T10:21:38.331ZS-EPMC85118013462835310.1016/j.ebiom.2021.103609