{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Heiney SA"],"funding":["NIMH NIH HHS","NINDS NIH HHS","National Institutes of Health"],"pagination":["2981-2994.e5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8513160"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["109(18)"],"pubmed_abstract":["The role of the cerebellum in predictive motor control and coordination has been thoroughly studied during movements of a single body part. In the real world, however, actions are often more complex. Here, we show that a small area in the rostral anterior interpositus nucleus (rAIN) of the mouse cerebellum is responsible for generating a predictive motor synergy that serves to protect the eye by precisely coordinating muscles of the eyelid, neck, and forelimb. Within the rAIN region, we discovered a new functional category of neurons with unique properties specialized for control of motor synergies. These neurons integrated inhibitory cutaneous inputs from multiple parts of the body, and their activity was correlated with the vigor of the defensive motor synergy on a trial-by-trial basis. "],"journal":["Neuron"],"pubmed_title":["Action-based organization of a cerebellar module specialized for predictive control of multiple body parts."],"pmcid":["PMC8513160"],"funding_grant_id":["NS104836","RF1 MH114269","R01 NS112917","MH093727","R21 NS104836","NS112917","R01 MH093727","MH114269"],"pubmed_authors":["Heiney SA","Wojaczynski GJ","Medina JF"],"additional_accession":[]},"is_claimable":false,"name":"Action-based organization of a cerebellar module specialized for predictive control of multiple body parts.","description":"The role of the cerebellum in predictive motor control and coordination has been thoroughly studied during movements of a single body part. In the real world, however, actions are often more complex. Here, we show that a small area in the rostral anterior interpositus nucleus (rAIN) of the mouse cerebellum is responsible for generating a predictive motor synergy that serves to protect the eye by precisely coordinating muscles of the eyelid, neck, and forelimb. Within the rAIN region, we discovered a new functional category of neurons with unique properties specialized for control of motor synergies. These neurons integrated inhibitory cutaneous inputs from multiple parts of the body, and their activity was correlated with the vigor of the defensive motor synergy on a trial-by-trial basis. ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-22T09:59:14.463Z","creation":"2025-04-05T23:24:25.333Z"},"accession":"S-EPMC8513160","cross_references":{"pubmed":["34534455"],"doi":["10.1016/j.neuron.2021.08.017"]}}