biostudies-literatureUnknown375Naghshi S<h4>Objective</h4>To examine the associations between dietary intake and tissue biomarkers of alpha linolenic acid (ALA) and risk of mortality from all causes, cardiovascular disease (CVD), and cancer.<h4>Design</h4>Systematic review and meta-analysis of prospective cohort studies.<h4>Data sources</h4>PubMed, Scopus, ISI Web of Science, and Google Scholar to 30 April 2021.<h4>Study selection</h4>Prospective cohort studies that reported the risk estimates for death from all causes, CVD, and cancer.<h4>Data synthesis</h4>Summary relative risks and 95% confidence intervals were calculated for the highest versus lowest categories of ALA intake using random effects and fixed effects models. Linear and non-linear dose-response analyses were conducted to assess the dose-response associations betwBMJ (Clinical research ed.)n2213https://www.ebi.ac.uk/biostudies/studies/S-EPMC8513503biostudies-literatureDietary intake and biomarkers of alpha linolenic acid and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of cohort studies.PMC8513503Aune DBeyene JNaghshi SAsadi MMobarak SSadeghi OfalseDietary intake and biomarkers of alpha linolenic acid and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of cohort studies.<h4>Objective</h4>To examine the associations between dietary intake and tissue biomarkers of alpha linolenic acid (ALA) and risk of mortality from all causes, cardiovascular disease (CVD), and cancer.<h4>Design</h4>Systematic review and meta-analysis of prospective cohort studies.<h4>Data sources</h4>PubMed, Scopus, ISI Web of Science, and Google Scholar to 30 April 2021.<h4>Study selection</h4>Prospective cohort studies that reported the risk estimates for death from all causes, CVD, and cancer.<h4>Data synthesis</h4>Summary relative risks and 95% confidence intervals were calculated for the highest versus lowest categories of ALA intake using random effects and fixed effects models. Linear and non-linear dose-response analyses were conducted to assess the dose-response associations betw2021-01-01T00:00:00Z2021 Oct2026-07-16T14:54:52.396Z2025-04-19T05:02:58.749ZS-EPMC85135033464565010.1136/bmj.n2213