biostudies-literatureUnknown102(8)Shimmon GLbiotechnology and biological sciences research councilBiotechnology and Biological Sciences Research CouncilAfrican swine fever is a devastating disease of domestic swine and wild boar caused by a large double-stranded DNA virus that encodes for more than 150 open reading frames. There is no licensed vaccine for the disease and the most promising current candidates are modified live viruses that have been attenuated by deletion of virulence factors. Like many viruses African swine fever virus significantly alters the host cell machinery to benefit its replication and viral genes that modify host pathways represent promising targets for development of gene deleted vaccines. Autophagy is an important cellular pathway that is involved in cellular homeostasis, innate and adaptive immunity and therefore is manipulated by a number of different viruses. Autophagy is regulated by a complex protein cascaThe Journal of general virologyhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC8513644biostudies-literatureAutophagy impairment by African swine fever virus.PMC8513644BBS/E/I/00001709BBS/E/I/00002120BBS/E/I/00007037BBS/E/I/00007039BB/R009988/1BBS/E/I/00007034Netherton CLHui JYKWileman TEShimmon GLfalseAutophagy impairment by African swine fever virus.African swine fever is a devastating disease of domestic swine and wild boar caused by a large double-stranded DNA virus that encodes for more than 150 open reading frames. There is no licensed vaccine for the disease and the most promising current candidates are modified live viruses that have been attenuated by deletion of virulence factors. Like many viruses African swine fever virus significantly alters the host cell machinery to benefit its replication and viral genes that modify host pathways represent promising targets for development of gene deleted vaccines. Autophagy is an important cellular pathway that is involved in cellular homeostasis, innate and adaptive immunity and therefore is manipulated by a number of different viruses. Autophagy is regulated by a complex protein casca2021-01-01T00:00:00Z2021 Aug2025-06-01T12:10:17.317Z2025-06-01T12:10:17.317ZS-EPMC85136443440611610.1099/jgv.0.001637