biostudies-literatureYang LDeutsche Forschungsgemeinschaft12971-12976https://www.ebi.ac.uk/biostudies/studies/S-EPMC8513870biostudies-literatureUnknown12(39)Copper-catalyzed electrochemical direct chalcogenations of <i>o</i>-carboranes was established at room temperature. Thereby, a series of cage C-sulfenylated and C-selenylated <i>o</i>-carboranes anchored with valuable functional groups was accessed with high levels of position- and chemo-selectivity control. The cupraelectrocatalysis provided efficient means to activate otherwise inert cage C-H bonds for the late-stage diversification of <i>o</i>-carboranes.Chemical scienceElectrooxidative <i>o</i>-carborane chalcogenations without directing groups: cage activation by copper catalysis at room temperature.PMC8513870Gottfried-Wilhelm-Leibniz prizeYang LJei BBStuckl ACYuan BScheremetjew AAckermann LfalseElectrooxidative <i>o</i>-carborane chalcogenations without directing groups: cage activation by copper catalysis at room temperature.Copper-catalyzed electrochemical direct chalcogenations of <i>o</i>-carboranes was established at room temperature. Thereby, a series of cage C-sulfenylated and C-selenylated <i>o</i>-carboranes anchored with valuable functional groups was accessed with high levels of position- and chemo-selectivity control. The cupraelectrocatalysis provided efficient means to activate otherwise inert cage C-H bonds for the late-stage diversification of <i>o</i>-carboranes.2021-01-01T00:00:00Z2021 Oct2025-06-01T00:56:50.18Z2025-06-01T00:56:50.18ZS-EPMC85138703474552710.1039/d1sc02905c