biostudies-literatureLi ZFundação para a Ciência e a TecnologiaChina Scholarship CouncilShanghai Ocean University725022https://www.ebi.ac.uk/biostudies/studies/S-EPMC8514136biostudies-literatureUnknown12The allatostatins (ASTs), AST-A, AST-B and AST-C, have mainly been investigated in insects. They are a large group of small pleotropic alloregulatory neuropeptides that are unrelated in sequence and activate receptors of the rhodopsin G-protein coupled receptor family (GPCRs). The characteristics and functions of the homologue systems in the molluscs (Buccalin, MIP and AST-C-like), the second most diverse group of protostomes after the arthropods, and of high interest for evolutionary studies due to their less rearranged genomes remains to be explored. In the present study their evolution is deciphered in molluscs and putative functions assigned in bivalves through meta-analysis of transcriptomes and experiments. Homologues of the three arthropod AST-type peptide precursors were identifiedFrontiers in endocrinologyEvolution and Potential Function in Molluscs of Neuropeptide and Receptor Homologues of the Insect Allatostatins.PMC8514136PhD grant to Maoxiao PengPhD grant to Zhi LiUIDB/04326/2020Power DMLi ZInacio JPSPeng MCardoso JCRfalseEvolution and Potential Function in Molluscs of Neuropeptide and Receptor Homologues of the Insect Allatostatins.The allatostatins (ASTs), AST-A, AST-B and AST-C, have mainly been investigated in insects. They are a large group of small pleotropic alloregulatory neuropeptides that are unrelated in sequence and activate receptors of the rhodopsin G-protein coupled receptor family (GPCRs). The characteristics and functions of the homologue systems in the molluscs (Buccalin, MIP and AST-C-like), the second most diverse group of protostomes after the arthropods, and of high interest for evolutionary studies due to their less rearranged genomes remains to be explored. In the present study their evolution is deciphered in molluscs and putative functions assigned in bivalves through meta-analysis of transcriptomes and experiments. Homologues of the three arthropod AST-type peptide precursors were identified2021-01-01T00:00:00Z20212026-05-09T20:36:26.095Z2022-02-11T12:13:45.248ZS-EPMC85141363465911610.3389/fendo.2021.725022