{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Brown JA"],"funding":["NCATS NIH HHS","NIMH NIH HHS","National Institute of Mental Health"],"pagination":["801-809"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8514149"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(8)"],"pubmed_abstract":["Objectives
Affective and psychotic features overlap considerably in bipolar I disorder, complicating efforts to determine its etiology and develop targeted treatments. In order to clarify whether mechanisms are similar or divergent for bipolar disorder with psychosis (BDP) and bipolar disorder with no psychosis (BDNP), neurobiological profiles for both the groups must first be established. This study examines white matter structure in the BDP and BDNP groups, in an effort to identify portions of white matter that may differ between the bipolar and healthy groups or between the bipolar subgroups themselves.Methods
Diffusion-weighted imaging data were acquired from participants with BDP (n = 45), BDNP (n = 40), and healthy comparisons (HC) (n = 66). Fractional anisotropy (FA)"],"journal":["Bipolar disorders"],"pubmed_title":["Reduced white matter microstructure in bipolar disorder with and without psychosis."],"pmcid":["PMC8514149"],"funding_grant_id":["R01 MH096900","R01 MH103368","R01 MH096957","R01 MH096913","MH096942","MH096900","R01 MH096942","MH096957","MH096913","UL1 TR001863"],"pubmed_authors":["Gershon ES","Pearlson GD","Clementz BA","Keshavan MS","Hoy JE","Brown JA","Jackson BS","Burton CR","Sweeney JA","McDowell JE","Keedy SS","Tamminga CA"],"additional_accession":[]},"is_claimable":false,"name":"Reduced white matter microstructure in bipolar disorder with and without psychosis.","description":"Objectives
Affective and psychotic features overlap considerably in bipolar I disorder, complicating efforts to determine its etiology and develop targeted treatments. In order to clarify whether mechanisms are similar or divergent for bipolar disorder with psychosis (BDP) and bipolar disorder with no psychosis (BDNP), neurobiological profiles for both the groups must first be established. This study examines white matter structure in the BDP and BDNP groups, in an effort to identify portions of white matter that may differ between the bipolar and healthy groups or between the bipolar subgroups themselves.Methods
Diffusion-weighted imaging data were acquired from participants with BDP (n = 45), BDNP (n = 40), and healthy comparisons (HC) (n = 66). Fractional anisotropy (FA)","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-04T19:38:06.24Z","creation":"2025-04-04T19:38:06.24Z"},"accession":"S-EPMC8514149","cross_references":{"pubmed":["33550654"],"doi":["10.1111/bdi.13055"]}}