biostudies-literatureSwerdlow NRNIMH NIH HHS140-148https://www.ebi.ac.uk/biostudies/studies/S-EPMC8514598biostudies-literatureUnknown53(1)<h4>Background</h4>Auditory frequency modulation learning ('auditory learning') is a key component of targeted cognitive training (TCT) for schizophrenia. TCT can be effective in enhancing neurocognition and function in schizophrenia, but such gains require significant time and effort and elude many patients.<h4>Methods</h4>As a strategy to increase and/or accelerate TCT-induced clinical gains, we tested the dose- and time-course effects of the pro-attentional drug, amphetamine (AMPH; placebo, 2.5, 5 or 10 mg po; within-subject double-blind, order balanced) on auditory learning in schizophrenia patients [<i>n</i> = 32; M:F = 19:13; age 42.0 years (24-55)]. To understand predictors and/or mechanisms of AMPH-enhanced TCT, we also measured auditory fidelity (words-in-noise (WIN), quick speechPsychological medicineAuditory discrimination and frequency modulation learning in schizophrenia patients: amphetamine within-subject dose response and time course.PMC8514598R01 MH059803R33 MH123603R25 MH101072R01 MH094320Molina JLBhakta SGKotz JTalledo JVinogradov SBenster LLight GASwerdlow NRfalseAuditory discrimination and frequency modulation learning in schizophrenia patients: amphetamine within-subject dose response and time course.<h4>Background</h4>Auditory frequency modulation learning ('auditory learning') is a key component of targeted cognitive training (TCT) for schizophrenia. TCT can be effective in enhancing neurocognition and function in schizophrenia, but such gains require significant time and effort and elude many patients.<h4>Methods</h4>As a strategy to increase and/or accelerate TCT-induced clinical gains, we tested the dose- and time-course effects of the pro-attentional drug, amphetamine (AMPH; placebo, 2.5, 5 or 10 mg po; within-subject double-blind, order balanced) on auditory learning in schizophrenia patients [<i>n</i> = 32; M:F = 19:13; age 42.0 years (24-55)]. To understand predictors and/or mechanisms of AMPH-enhanced TCT, we also measured auditory fidelity (words-in-noise (WIN), quick speech2023-01-01T00:00:00Z2023 Jan2026-03-27T16:14:15.816Z2025-08-28T03:07:12.4ZS-EPMC85145983384968310.1017/S0033291721001239