{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gaudette BT"],"funding":["NIAID NIH HHS","NCI NIH HHS","NIAID"],"pagination":["e151975"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8516456"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["131(20)"],"pubmed_abstract":["Little is known about how cells regulate and integrate distinct biosynthetic pathways governing differentiation and cell division. For B lineage cells it is widely accepted that activated cells must complete several rounds of mitosis before yielding antibody-secreting plasma cells. However, we report that marginal zone (MZ) B cells, innate-like naive B cells known to generate plasma cells rapidly in response to blood-borne bacteria, generate functional plasma cells despite cell-cycle arrest. Further, short-term Notch2 blockade in vivo reversed division-independent differentiation potential and decreased transcript abundance for numerous mTORC1- and Myc-regulated genes. Myc loss compromised plasma cell differentiation for MZ B cells, and reciprocally induced ectopic mTORC1 signaling in foll"],"journal":["The Journal of clinical investigation"],"pubmed_title":["Resting innate-like B cells leverage sustained Notch2/mTORC1 signaling to achieve rapid and mitosis-independent plasma cell differentiation."],"pmcid":["PMC8516456"],"funding_grant_id":["R01 AI091627","T32 CA009140","AI154932","R01 AI154932","AI139123","R01 AI139123"],"pubmed_authors":["Ochoa TA","Siebel CW","Roman CJ","Jones DD","Allman D","Gomez Atria D","Maillard I","Gaudette BT"],"additional_accession":[]},"is_claimable":false,"name":"Resting innate-like B cells leverage sustained Notch2/mTORC1 signaling to achieve rapid and mitosis-independent plasma cell differentiation.","description":"Little is known about how cells regulate and integrate distinct biosynthetic pathways governing differentiation and cell division. For B lineage cells it is widely accepted that activated cells must complete several rounds of mitosis before yielding antibody-secreting plasma cells. However, we report that marginal zone (MZ) B cells, innate-like naive B cells known to generate plasma cells rapidly in response to blood-borne bacteria, generate functional plasma cells despite cell-cycle arrest. Further, short-term Notch2 blockade in vivo reversed division-independent differentiation potential and decreased transcript abundance for numerous mTORC1- and Myc-regulated genes. Myc loss compromised plasma cell differentiation for MZ B cells, and reciprocally induced ectopic mTORC1 signaling in foll","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-05-08T09:00:41.218Z","creation":"2022-02-11T16:18:22.409Z"},"accession":"S-EPMC8516456","cross_references":{"pubmed":["34473651"],"doi":["10.1172/JCI151975","10.1172/jci151975"]}}