{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["64(1)"],"submitter":["Ohi K"],"pubmed_abstract":["<h4>Background</h4>Intelligence is inversely associated with schizophrenia (SCZ) and bipolar disorder (BD); it remains unclear whether low intelligence is a cause or consequence. We investigated causal associations of intelligence with SCZ or BD risk and a shared risk between SCZ and BD and SCZ-specific risk.<h4>Methods</h4>To estimate putative causal associations, we performed multi-single nucleotide polymorphism (SNP) Mendelian randomization (MR) using generalized summary-data-based MR (GSMR). Summary-level datasets from five GWASs (intelligence, SCZ vs. control [CON], BD vs. CON, SCZ + BD vs. CON, and SCZ vs. BD; sample sizes of up to 269,867) were utilized.<h4>Results</h4>A strong bidirectional association between risks for SCZ and BD was observed (odds ratio; ORSCZ → BD = 1.47, p = 2."],"journal":["European psychiatry : the journal of the Association of European Psychiatrists"],"pagination":["e61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8516746"],"repository":["biostudies-literature"],"pubmed_title":["Causal associations of intelligence with schizophrenia and bipolar disorder: A Mendelian randomization analysis."],"pmcid":["PMC8516746"],"pubmed_authors":["Ohi K","Sugiyama S","Takai K","Shioiri T","Kitaichi K","Kuramitsu A","Soda M"],"additional_accession":[]},"is_claimable":false,"name":"Causal associations of intelligence with schizophrenia and bipolar disorder: A Mendelian randomization analysis.","description":"<h4>Background</h4>Intelligence is inversely associated with schizophrenia (SCZ) and bipolar disorder (BD); it remains unclear whether low intelligence is a cause or consequence. We investigated causal associations of intelligence with SCZ or BD risk and a shared risk between SCZ and BD and SCZ-specific risk.<h4>Methods</h4>To estimate putative causal associations, we performed multi-single nucleotide polymorphism (SNP) Mendelian randomization (MR) using generalized summary-data-based MR (GSMR). Summary-level datasets from five GWASs (intelligence, SCZ vs. control [CON], BD vs. CON, SCZ + BD vs. CON, and SCZ vs. BD; sample sizes of up to 269,867) were utilized.<h4>Results</h4>A strong bidirectional association between risks for SCZ and BD was observed (odds ratio; ORSCZ → BD = 1.47, p = 2.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-04T22:43:10.135Z","creation":"2025-04-04T22:43:10.135Z"},"accession":"S-EPMC8516746","cross_references":{"pubmed":["34641990"],"doi":["10.1192/j.eurpsy.2021.2237"]}}