{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang H"],"funding":["Intramural NIH HHS","NIA NIH HHS","NIDDK NIH HHS","NHLBI NIH HHS","U.S. Department of Health &amp; Human Services | NIH | National Heart, Lung, and Blood Institute","U.S. Department of Health &amp; Human Services | NIH | National Institute on Minority Health and Health Disparities","NCI NIH HHS","EC | European Commission - Executive Agency for SMEs | Competitiveness of Enterprises and Small and Medium-sized Enterprises","NNF Center for Basic Metabolic Research","Novo Nordisk Fonden"],"pagination":["6293-6304"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8517040"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(11)"],"pubmed_abstract":["Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide gene by short or long sleep duration interaction analyses on four BP traits (systolic BP, diastolic BP, mean arterial pressure, and pulse pressure) across five ancestry groups in two stages using 2 degree of freedom (df) joint test followed by 1df test of interaction effects. Primary multi-ancestry analysis in 62,969 individuals in stage 1 identified three novel gene by sleep interactions that were replicated in an additional 59,296 individuals in stage 2 (stage 1 + 2 P<sub>joint</sub> < 5 × 10<sup>-8</sup>), includ"],"journal":["Molecular psychiatry"],"pubmed_title":["Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure."],"pmcid":["PMC8517040"],"funding_grant_id":["R01 AG058921","K01 HL135405","NNF17OC0026848","K01HL135405","R21-HL140385","R01-MD012765","R35HL135818","T32 CA112355","R03 HL154284","R01 HL118305","R01 HL113338","R01 HL153814","R01HL118305","Kilpeläinen Group","R35 HL135818","ZIA HG200362","P30 DK079626","R01 HL046380","U19 CA203654","R01 HL105756","R01 HL086694","Health-2013-INNOVATION-1-602757"],"pubmed_authors":["Psaty BM","Uitterlinden AG","Guo X","Rice K","Zee PC","Gudnason V","Morrison AC","Richard M","Harris SE","Deary IJ","Hall KA","Ikram MA","Mook-Kanamori DO","Grabe HJ","Sung YJ","Roenneberg T","Nolte IM","Esko T","Luik AI","He J","Milani L","Palmer LJ","Musani SK","Palmas W","Xu H","Zheng W","Bartz TM","Gharib SA","Redline S","Lyytikainen LP","Strauch K","Horimoto AR","Sidney S","Schwander K","Levy D","Noordam R","Mukherjee S","Rauramaa R","Biermasz NR","Amin N","Waldenberger M","Lee J","Lohman KK","Munroe PB","Penninx BWJH","Gauderman WJ","Wagenknecht LE","Brown MR","Eiriksdottir G","Rankinen T","Sims M","Bouchard C","Pereira AC","Gottlieb DJ","Vojinovic D","Barac A","Martin LW","Volker U","Palmer ND","Milaneschi Y","Aschard H","Bis JC","Arking DE","Nierenberg JL","Rice TK","Starr JM","Wilson G","Kooperberg C","Fox ER","Komulainen P","Zhu X","Wallace RB","Lakka TA","de Vries PS","Manning AK","Peters A","Rotter JI","Boerwinkle E","Rich SS","Wang H","Wen W","Gao C","Zonderman AB","Meitinger T","Krieger JE","Yao J","Gieger C","Magi R","Franceschini N","Kahonen M","Chen H","Schreiner PJ","Heikkinen S","van Duijn CM","Evans MK","Kilpelainen TO","Liu CT","O'Connell J","Kelly TN","Chitrala K","Fornage M","Dorr M","van der Most PJ","Winkler TW","Alver M","Bentley AR","Liu Y","Ilkov M","Sofer T","Hillman DR","Weiss S","Lehtimaki T","Metspalu A","Shu XO","Rao DC","Snieder H","Shikany JM","Cade BE","Lim E","Waken RJ","Launer LJ","van Heemst D","Chen YI","Kuhnel B","North KE"],"additional_accession":[]},"is_claimable":false,"name":"Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.","description":"Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide gene by short or long sleep duration interaction analyses on four BP traits (systolic BP, diastolic BP, mean arterial pressure, and pulse pressure) across five ancestry groups in two stages using 2 degree of freedom (df) joint test followed by 1df test of interaction effects. Primary multi-ancestry analysis in 62,969 individuals in stage 1 identified three novel gene by sleep interactions that were replicated in an additional 59,296 individuals in stage 2 (stage 1 + 2 P<sub>joint</sub> < 5 × 10<sup>-8</sup>), includ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-05-31T06:05:54.035Z","creation":"2025-02-19T01:55:17.539Z"},"accession":"S-EPMC8517040","cross_references":{"pubmed":["33859359"],"doi":["10.1038/s41380-021-01087-0"]}}