biostudies-literatureUnknown8(3)Shin J<h4>Objective</h4>Although fluid resuscitation is the cornerstone of treatment for sepsis, the role of body water status in sepsis is poorly understood. This study aimed to understand how body water and its distribution are modified in patients with sepsis and those with non-septic infection compared to healthy individuals.<h4>Methods</h4>Two groups of adults presumed to have non-septic infection (n=87) and sepsis (n=54) were enrolled in this prospective study in a single emergency department, and they were compared to sex-, age-, and height-matched (1:3 ratio) healthy controls (n=11,190) from retrospective data in a health promotion center. Total body water (TBW), intracellular water (ICW), and extracellular water (ECW), determined using direct segmental multi-frequent bioelectrical impedClinical and experimental emergency medicine173-181https://www.ebi.ac.uk/biostudies/studies/S-EPMC8517463biostudies-literatureComparison of body water status and its distribution in patients with non-septic infection, patients with sepsis, and healthy controls.PMC8517463Lee SMHan JSPark IKim BJang DHShin JLee CULee JHJo YHfalseComparison of body water status and its distribution in patients with non-septic infection, patients with sepsis, and healthy controls.<h4>Objective</h4>Although fluid resuscitation is the cornerstone of treatment for sepsis, the role of body water status in sepsis is poorly understood. This study aimed to understand how body water and its distribution are modified in patients with sepsis and those with non-septic infection compared to healthy individuals.<h4>Methods</h4>Two groups of adults presumed to have non-septic infection (n=87) and sepsis (n=54) were enrolled in this prospective study in a single emergency department, and they were compared to sex-, age-, and height-matched (1:3 ratio) healthy controls (n=11,190) from retrospective data in a health promotion center. Total body water (TBW), intracellular water (ICW), and extracellular water (ECW), determined using direct segmental multi-frequent bioelectrical imped2021-01-01T00:00:00Z2021 Sep2025-05-29T20:55:18.733Z2025-05-29T20:55:18.733ZS-EPMC85174633464940510.15441/ceem.20.094