{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jordan PM"],"funding":["Deutsche Forschungsgemeinschaft","Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Jena"],"pagination":["541-554"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8517600"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["164(3)"],"pubmed_abstract":["IL-33 and ATP are alarmins, which are released upon damage of cellular barriers or are actively secreted upon cell stress. Due to high-density expression of the IL-33 receptor T1/ST2 (IL-33R), and the ATP receptor P2X7, mast cells (MCs) are one of the first highly sensitive sentinels recognizing released IL-33 or ATP in damaged peripheral tissues. Whereas IL-33 induces the MyD88-dependent activation of the TAK1-IKK2-NF-κB signalling, ATP induces the Ca<sup>2+</sup> -dependent activation of NFAT. Thereby, each signal alone only induces a moderate production of pro-inflammatory cytokines and lipid mediators (LMs). However, MCs, which simultaneously sense (co-sensing) IL-33 and ATP, display an enhanced and prolonged activation of the TAK1-IKK2-NF-κB signalling pathway. This resulted in a mass"],"journal":["Immunology"],"pubmed_title":["ATP/IL-33-triggered hyperactivation of mast cells results in an amplified production of pro-inflammatory cytokines and eicosanoids."],"pmcid":["PMC8517600"],"funding_grant_id":["DFG DR1113/1-1","CRC854/A28N","316213987","SFB1278/1","IZKF-MSP-1","DFG DR1113/1‐1","RTG 2408/TP4"],"pubmed_authors":["Groth M","Dudeck A","Drube S","Kuchler C","Serfling E","Jordan PM","Weber F","Andreas N","Jager U","Wegner P","Kamradt T","Werz O"],"additional_accession":[]},"is_claimable":false,"name":"ATP/IL-33-triggered hyperactivation of mast cells results in an amplified production of pro-inflammatory cytokines and eicosanoids.","description":"IL-33 and ATP are alarmins, which are released upon damage of cellular barriers or are actively secreted upon cell stress. Due to high-density expression of the IL-33 receptor T1/ST2 (IL-33R), and the ATP receptor P2X7, mast cells (MCs) are one of the first highly sensitive sentinels recognizing released IL-33 or ATP in damaged peripheral tissues. Whereas IL-33 induces the MyD88-dependent activation of the TAK1-IKK2-NF-κB signalling, ATP induces the Ca<sup>2+</sup> -dependent activation of NFAT. Thereby, each signal alone only induces a moderate production of pro-inflammatory cytokines and lipid mediators (LMs). However, MCs, which simultaneously sense (co-sensing) IL-33 and ATP, display an enhanced and prolonged activation of the TAK1-IKK2-NF-κB signalling pathway. This resulted in a mass","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-22T11:27:09.355Z","creation":"2025-04-06T00:01:09.754Z"},"accession":"S-EPMC8517600","cross_references":{"pubmed":["34142370"],"doi":["10.1111/imm.13386"]}}