{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["131(4)"],"submitter":["Watanabe J"],"funding":["Grants from Kagome Co. Ltd."],"pubmed_abstract":["<h4>Aims</h4>This study aimed to evaluate the anti-adiposity effect of heat-killed Lactobacillus brevis KB290 originating from traditional Japanese fermented pickles in mice fed a high-fat diet (HFD).<h4>Methods and results</h4>C57BL/6J mice were fed a normal-fat diet, HFD or HFD supplemented with heat-killed KB290 for 8 weeks. Epididymal and renal adipose tissue weights, as well as areas of epididymal adipocytes, were significantly lower in the mice fed a HFD supplemented with KB290 than in those fed an unsupplemented HFD. Mice whose diets were supplemented with KB290 had elevated adiponectin and β3-adrenergic receptor expression in epididymal adipose tissue and an accompanying higher serum free fatty acid level. Furthermore, the HFD-induced elevations in serum glucose, insulin and HOMA-I"],"journal":["Journal of applied microbiology"],"pagination":["1998-2009"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8518035"],"repository":["biostudies-literature"],"pubmed_title":["Heat-killed Lactobacillus brevis KB290 attenuates visceral fat accumulation induced by high-fat diet in mice."],"pmcid":["PMC8518035"],"pubmed_authors":["Inoue T","Suzuki S","Arakawa C","Watanabe J","Yin T","Hashimoto N","Sandagdorj B"],"additional_accession":[]},"is_claimable":false,"name":"Heat-killed Lactobacillus brevis KB290 attenuates visceral fat accumulation induced by high-fat diet in mice.","description":"<h4>Aims</h4>This study aimed to evaluate the anti-adiposity effect of heat-killed Lactobacillus brevis KB290 originating from traditional Japanese fermented pickles in mice fed a high-fat diet (HFD).<h4>Methods and results</h4>C57BL/6J mice were fed a normal-fat diet, HFD or HFD supplemented with heat-killed KB290 for 8 weeks. Epididymal and renal adipose tissue weights, as well as areas of epididymal adipocytes, were significantly lower in the mice fed a HFD supplemented with KB290 than in those fed an unsupplemented HFD. Mice whose diets were supplemented with KB290 had elevated adiponectin and β3-adrenergic receptor expression in epididymal adipose tissue and an accompanying higher serum free fatty acid level. Furthermore, the HFD-induced elevations in serum glucose, insulin and HOMA-I","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-04T09:18:41.497Z","creation":"2025-04-04T09:18:41.497Z"},"accession":"S-EPMC8518035","cross_references":{"pubmed":["33742756"],"doi":["10.1111/jam.15079"]}}