biostudies-literatureUnknown131(4)Watanabe JGrants from Kagome Co. Ltd.<h4>Aims</h4>This study aimed to evaluate the anti-adiposity effect of heat-killed Lactobacillus brevis KB290 originating from traditional Japanese fermented pickles in mice fed a high-fat diet (HFD).<h4>Methods and results</h4>C57BL/6J mice were fed a normal-fat diet, HFD or HFD supplemented with heat-killed KB290 for 8 weeks. Epididymal and renal adipose tissue weights, as well as areas of epididymal adipocytes, were significantly lower in the mice fed a HFD supplemented with KB290 than in those fed an unsupplemented HFD. Mice whose diets were supplemented with KB290 had elevated adiponectin and β3-adrenergic receptor expression in epididymal adipose tissue and an accompanying higher serum free fatty acid level. Furthermore, the HFD-induced elevations in serum glucose, insulin and HOMA-IJournal of applied microbiology1998-2009https://www.ebi.ac.uk/biostudies/studies/S-EPMC8518035biostudies-literatureHeat-killed Lactobacillus brevis KB290 attenuates visceral fat accumulation induced by high-fat diet in mice.PMC8518035Inoue TSuzuki SArakawa CWatanabe JYin THashimoto NSandagdorj BfalseHeat-killed Lactobacillus brevis KB290 attenuates visceral fat accumulation induced by high-fat diet in mice.<h4>Aims</h4>This study aimed to evaluate the anti-adiposity effect of heat-killed Lactobacillus brevis KB290 originating from traditional Japanese fermented pickles in mice fed a high-fat diet (HFD).<h4>Methods and results</h4>C57BL/6J mice were fed a normal-fat diet, HFD or HFD supplemented with heat-killed KB290 for 8 weeks. Epididymal and renal adipose tissue weights, as well as areas of epididymal adipocytes, were significantly lower in the mice fed a HFD supplemented with KB290 than in those fed an unsupplemented HFD. Mice whose diets were supplemented with KB290 had elevated adiponectin and β3-adrenergic receptor expression in epididymal adipose tissue and an accompanying higher serum free fatty acid level. Furthermore, the HFD-induced elevations in serum glucose, insulin and HOMA-I2021-01-01T00:00:00Z2021 Oct2025-04-04T09:18:41.497Z2025-04-04T09:18:41.497ZS-EPMC85180353374275610.1111/jam.15079