{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["36(9)"],"submitter":["Mou H"],"pubmed_abstract":["<h4>Background and aim</h4>Programmed cell death-ligand 1 (PD-L1) immunohistochemistry score has been approved as the predictive biomarker for anti-PD1/PD-L1 therapy in several advanced malignancies. Although its predictive role remained inconclusive in hepatocellular carcinoma, ongoing study of anti-PD1/PD-L1 therapy showed promising results. However, less is known about the PD-L1 immunohistochemistry score and factors correlated with it in hepatocellular carcinoma. We investigated PD-L1 immunohistochemistry scores in a large cohort of hepatocellular carcinoma, as well as its correlation with various clinical and genomic factors.<h4>Methods</h4>Immunohistochemistry was performed to detect the expression of PD-L1 protein in 315 hepatocellular carcinoma tissues. All slides were independentl"],"journal":["Journal of gastroenterology and hepatology"],"pagination":["2601-2609"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8518358"],"repository":["biostudies-literature"],"pubmed_title":["Programmed cell death-ligand 1 expression in hepatocellular carcinoma and its correlation with clinicopathological characteristics."],"pmcid":["PMC8518358"],"pubmed_authors":["Pan X","Yang QA","Yu L","Wan Q","Liu K","Dong X","Mou H","Dai Y","Chen D","Yau T","Wang S","Wang T","Shen R","Zhou F","Wang X","Qian L"],"additional_accession":[]},"is_claimable":false,"name":"Programmed cell death-ligand 1 expression in hepatocellular carcinoma and its correlation with clinicopathological characteristics.","description":"<h4>Background and aim</h4>Programmed cell death-ligand 1 (PD-L1) immunohistochemistry score has been approved as the predictive biomarker for anti-PD1/PD-L1 therapy in several advanced malignancies. Although its predictive role remained inconclusive in hepatocellular carcinoma, ongoing study of anti-PD1/PD-L1 therapy showed promising results. However, less is known about the PD-L1 immunohistochemistry score and factors correlated with it in hepatocellular carcinoma. We investigated PD-L1 immunohistochemistry scores in a large cohort of hepatocellular carcinoma, as well as its correlation with various clinical and genomic factors.<h4>Methods</h4>Immunohistochemistry was performed to detect the expression of PD-L1 protein in 315 hepatocellular carcinoma tissues. All slides were independentl","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-19T15:10:06.068Z","creation":"2025-02-19T00:18:43.672Z"},"accession":"S-EPMC8518358","cross_references":{"pubmed":["33656759"],"doi":["10.1111/jgh.15475"]}}