biostudies-literatureUnknown36(9)Mou H<h4>Background and aim</h4>Programmed cell death-ligand 1 (PD-L1) immunohistochemistry score has been approved as the predictive biomarker for anti-PD1/PD-L1 therapy in several advanced malignancies. Although its predictive role remained inconclusive in hepatocellular carcinoma, ongoing study of anti-PD1/PD-L1 therapy showed promising results. However, less is known about the PD-L1 immunohistochemistry score and factors correlated with it in hepatocellular carcinoma. We investigated PD-L1 immunohistochemistry scores in a large cohort of hepatocellular carcinoma, as well as its correlation with various clinical and genomic factors.<h4>Methods</h4>Immunohistochemistry was performed to detect the expression of PD-L1 protein in 315 hepatocellular carcinoma tissues. All slides were independentlJournal of gastroenterology and hepatology2601-2609https://www.ebi.ac.uk/biostudies/studies/S-EPMC8518358biostudies-literatureProgrammed cell death-ligand 1 expression in hepatocellular carcinoma and its correlation with clinicopathological characteristics.PMC8518358Pan XYang QAYu LWan QLiu KDong XMou HDai YChen DYau TWang SWang TShen RZhou FWang XQian LfalseProgrammed cell death-ligand 1 expression in hepatocellular carcinoma and its correlation with clinicopathological characteristics.<h4>Background and aim</h4>Programmed cell death-ligand 1 (PD-L1) immunohistochemistry score has been approved as the predictive biomarker for anti-PD1/PD-L1 therapy in several advanced malignancies. Although its predictive role remained inconclusive in hepatocellular carcinoma, ongoing study of anti-PD1/PD-L1 therapy showed promising results. However, less is known about the PD-L1 immunohistochemistry score and factors correlated with it in hepatocellular carcinoma. We investigated PD-L1 immunohistochemistry scores in a large cohort of hepatocellular carcinoma, as well as its correlation with various clinical and genomic factors.<h4>Methods</h4>Immunohistochemistry was performed to detect the expression of PD-L1 protein in 315 hepatocellular carcinoma tissues. All slides were independentl2021-01-01T00:00:00Z2021 Sep2025-04-19T15:10:06.068Z2025-02-19T00:18:43.672ZS-EPMC85183583365675910.1111/jgh.15475