{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["194(6)"],"submitter":["Malinowski AK"],"pubmed_abstract":["We aimed to identify risk factors for adverse outcomes in pregnancies of women with sickle cell disease (SCD) and develop risk prediction models. Models were derived from a retrospective cohort of pregnant women with SCD and constructed using generalised estimating equation logistic regression, with clustering by woman. Maternal event(s) consisted of acute anaemia; cardiac, pulmonary, hepatobiliary, musculoskeletal, skin, splenic, neurological or renal complications, multi-organ failure, venous thromboembolism, admission-requiring vaso-occlusive events (VOE), red cell transfusion, mortality or hypertensive disorder of pregnancy. Fetal events included preterm birth, small-for-gestational-age or perinatal mortality. Of 199 pregnancies, 71% and 45% resulted in adverse maternal and fetal outco"],"journal":["British journal of haematology"],"pagination":["1063-1073"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8518407"],"repository":["biostudies-literature"],"pubmed_title":["Distinct maternal and fetal pregnancy outcomes in women with sickle cell disease can be predicted using routine clinical and laboratory data."],"pmcid":["PMC8518407"],"pubmed_authors":["Shehata N","Kuo KHM","Palcu P","Malinowski AK","Tomlinson GA","Ward R"],"additional_accession":[]},"is_claimable":false,"name":"Distinct maternal and fetal pregnancy outcomes in women with sickle cell disease can be predicted using routine clinical and laboratory data.","description":"We aimed to identify risk factors for adverse outcomes in pregnancies of women with sickle cell disease (SCD) and develop risk prediction models. Models were derived from a retrospective cohort of pregnant women with SCD and constructed using generalised estimating equation logistic regression, with clustering by woman. Maternal event(s) consisted of acute anaemia; cardiac, pulmonary, hepatobiliary, musculoskeletal, skin, splenic, neurological or renal complications, multi-organ failure, venous thromboembolism, admission-requiring vaso-occlusive events (VOE), red cell transfusion, mortality or hypertensive disorder of pregnancy. Fetal events included preterm birth, small-for-gestational-age or perinatal mortality. Of 199 pregnancies, 71% and 45% resulted in adverse maternal and fetal outco","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2026-03-27T17:06:06.832Z","creation":"2025-05-18T12:31:17.687Z"},"accession":"S-EPMC8518407","cross_references":{"pubmed":["34124774"],"doi":["10.1111/bjh.17607"]}}