{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Piras CC"],"funding":["Engineering and Physical Sciences Research Council"],"pagination":["13203-13210"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8519141"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(52)"],"pubmed_abstract":["This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH<sub>2</sub> , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach. We also demonstrate that self-assembled multicomponent gel beads can be formed by using different combinations of these gelators. The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads,"],"journal":["Chemistry (Weinheim an der Bergstrasse, Germany)"],"pubmed_title":["Hybrid Self-Assembled Gel Beads for Tuneable pH-Controlled Rosuvastatin Delivery."],"pmcid":["PMC8519141"],"funding_grant_id":["EP/P03361X/1"],"pubmed_authors":["Piras CC","Patterson AK","Smith DK"],"additional_accession":[]},"is_claimable":false,"name":"Hybrid Self-Assembled Gel Beads for Tuneable pH-Controlled Rosuvastatin Delivery.","description":"This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH<sub>2</sub> , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach. We also demonstrate that self-assembled multicomponent gel beads can be formed by using different combinations of these gelators. The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads,","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-19T15:10:35.881Z","creation":"2025-04-19T15:10:35.881Z"},"accession":"S-EPMC8519141","cross_references":{"pubmed":["34346527"],"doi":["10.1002/chem.202101405"]}}