biostudies-literaturePiras CCEngineering and Physical Sciences Research Council13203-13210https://www.ebi.ac.uk/biostudies/studies/S-EPMC8519141biostudies-literatureUnknown27(52)This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH₂ , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach. We also demonstrate that self-assembled multicomponent gel beads can be formed by using different combinations of these gelators. The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads,Chemistry (Weinheim an der Bergstrasse, Germany)Hybrid Self-Assembled Gel Beads for Tuneable pH-Controlled Rosuvastatin Delivery.PMC8519141EP/P03361X/1Piras CCPatterson AKSmith DKfalseHybrid Self-Assembled Gel Beads for Tuneable pH-Controlled Rosuvastatin Delivery.This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH₂ , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach. We also demonstrate that self-assembled multicomponent gel beads can be formed by using different combinations of these gelators. The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads,2021-01-01T00:00:00Z2021 Sep2025-04-19T15:10:35.881Z2025-04-19T15:10:35.881ZS-EPMC85191413434652710.1002/chem.202101405