biostudies-literatureUnknown8Zhang YStress diarrhea is a major challenge for weaned piglets and restricts pig production efficiency and incurs massive economic losses. A traditional Chinese medicine prescription (QJC) composed of <i>Astragalus propinquus</i> Schischkin (HQ), <i>Zingiber officinale</i> Roscoe (SJ), and <i>Plantago asiatica</i> L. (CQC) has been developed by our laboratory and shows marked anti-stress diarrhea effect. However, the active compounds, potential targets, and mechanism of this effect remain unclear and warrant further investigation. In our study, we verified the bioactive compounds of QJC and relevant mechanisms underlying the anti-stress diarrhea effect through network pharmacology and <i>in vivo</i> experimental studies. After establishing a successful stress-induced diarrhea model, histomorpholoFrontiers in veterinary science724491https://www.ebi.ac.uk/biostudies/studies/S-EPMC8520981biostudies-literatureStudy on the Effective Material Basis and Mechanism of Traditional Chinese Medicine Prescription (QJC) Against Stress Diarrhea in Mice.PMC8520981Li YHao JZhang YYu FNsabimana ELiu CWang XWei YChang XfalseStudy on the Effective Material Basis and Mechanism of Traditional Chinese Medicine Prescription (QJC) Against Stress Diarrhea in Mice.Stress diarrhea is a major challenge for weaned piglets and restricts pig production efficiency and incurs massive economic losses. A traditional Chinese medicine prescription (QJC) composed of <i>Astragalus propinquus</i> Schischkin (HQ), <i>Zingiber officinale</i> Roscoe (SJ), and <i>Plantago asiatica</i> L. (CQC) has been developed by our laboratory and shows marked anti-stress diarrhea effect. However, the active compounds, potential targets, and mechanism of this effect remain unclear and warrant further investigation. In our study, we verified the bioactive compounds of QJC and relevant mechanisms underlying the anti-stress diarrhea effect through network pharmacology and <i>in vivo</i> experimental studies. After establishing a successful stress-induced diarrhea model, histomorpholo2021-01-01T00:00:00Z20212026-03-27T16:15:18.198Z2025-05-18T10:37:12.282ZS-EPMC85209813467166110.3389/fvets.2021.724491