{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Gabbia D"],"funding":["Università degli Studi di Padova"],"pubmed_abstract":["Liver fibrosis, which is the outcome of wound-healing response to chronic liver damage, represents an unmet clinical need. This study evaluated the anti-fibrotic and anti-inflammatory effects of the polyphenol oleocanthal (OC) extracted from extra virgin olive oil (EVOO) by an <i>in vitro/in vivo</i> approach. The hepatic cell lines LX2 and HepG2 were used as <i>in vitro</i> models. The mRNA expression of pro-fibrogenic markers, namely alpha-smooth muscle actin (α-SMA), collagen type I alpha 1 chain (COL1A1), a panel of metalloproteinases (MMP1, MMP2, MMP3, MMP7, MMP9) and vascular endothelial growth factor A (VEGFA) as well as the pro-oxidant genes NADPH oxidases (NOXs) 1 and 4 were evaluated in TGF-β activated LX2 cells by qRT-PCR. α-SMA and COL1A1 protein expression was assessed by immu"],"journal":["Frontiers in nutrition"],"pagination":["715183"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8521071"],"repository":["biostudies-literature"],"pubmed_title":["The Extra Virgin Olive Oil Polyphenol Oleocanthal Exerts Antifibrotic Effects in the Liver."],"pmcid":["PMC8521071"],"pubmed_authors":["Esposito Salsano J","Russo FP","Polini B","Carpi S","Colognesi M","Nieri P","Carrara M","Sarcognato S","Digiacomo M","Guido M","Manera C","Scaffidi M","Macchia M","Cannella L","Gabbia D","De Martin S"],"additional_accession":[]},"is_claimable":false,"name":"The Extra Virgin Olive Oil Polyphenol Oleocanthal Exerts Antifibrotic Effects in the Liver.","description":"Liver fibrosis, which is the outcome of wound-healing response to chronic liver damage, represents an unmet clinical need. This study evaluated the anti-fibrotic and anti-inflammatory effects of the polyphenol oleocanthal (OC) extracted from extra virgin olive oil (EVOO) by an <i>in vitro/in vivo</i> approach. The hepatic cell lines LX2 and HepG2 were used as <i>in vitro</i> models. The mRNA expression of pro-fibrogenic markers, namely alpha-smooth muscle actin (α-SMA), collagen type I alpha 1 chain (COL1A1), a panel of metalloproteinases (MMP1, MMP2, MMP3, MMP7, MMP9) and vascular endothelial growth factor A (VEGFA) as well as the pro-oxidant genes NADPH oxidases (NOXs) 1 and 4 were evaluated in TGF-β activated LX2 cells by qRT-PCR. α-SMA and COL1A1 protein expression was assessed by immu","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-21T14:48:42.415Z","creation":"2025-04-21T14:48:42.415Z"},"accession":"S-EPMC8521071","cross_references":{"pubmed":["34671630"],"doi":["10.3389/fnut.2021.715183"]}}