biostudies-literatureRudilosso SFondo de Investigacions Sanitarias of the Institut de Salud Carlos III to Ángel Chamorro and Xabier UrraFondo Europeo de Desarrollo RegionalInstitute of Health Carlos IIIEuropean Social FundInstituto de Salud Carlos III401-410https://www.ebi.ac.uk/biostudies/studies/S-EPMC8521260biostudies-literatureUnknown23(3)<h4>Background and purpose</h4> In real-world practice, the benefit of mechanical thrombectomy (MT) is uncertain in stroke patients with very favorable or poor prognostic profiles at baseline. We studied the effectiveness of MT versus medical treatment stratifying by different baseline prognostic factors.<h4>Methods</h4> Retrospective analysis of 2,588 patients with an ischemic stroke due to large vessel occlusion nested in the population-based registry of stroke code activations in Catalonia from January 2017 to June 2019. The effect of MT on good functional outcome (modified Rankin Score ≤2) and survival at 3 months was studied using inverse probability of treatment weighting (IPTW) analysis in three pre-defined baseline prognostic groups: poor (if pre-stroke disability, age >85 years, NJournal of strokeEffectiveness of Thrombectomy in Stroke According to Baseline Prognostic Factors: Inverse Probability of Treatment Weighting Analysis of a Population-Based Registry.PMC8521260FIS-ISCIII PI18/00444INT19/00020CM18/00116Molina CSanjurjo EAmaro SBaiges JAragones JMRudilosso SGomis MLlull LRenu ARios JLopez MNCocho DRodriguez AMatos Nde la Ossa NPCanovas DJimenez-Fabrega FXTerceno MCardona PRoman LSTorres FUstrell XAlmendros MCGomez-Choco MSalvat-Plana MSerena JUrra XObach VRodriguez-Campello AMarti-Fabregas JCatena ERybyeba MBarcelo MCarrion DPurroy FColom CVera VChamorro ADiaz GCosta XPalomeras ECatalan Stroke Code and Reperfusion (Cat-SCR) ConsortiumKrupinski JfalseEffectiveness of Thrombectomy in Stroke According to Baseline Prognostic Factors: Inverse Probability of Treatment Weighting Analysis of a Population-Based Registry.<h4>Background and purpose</h4> In real-world practice, the benefit of mechanical thrombectomy (MT) is uncertain in stroke patients with very favorable or poor prognostic profiles at baseline. We studied the effectiveness of MT versus medical treatment stratifying by different baseline prognostic factors.<h4>Methods</h4> Retrospective analysis of 2,588 patients with an ischemic stroke due to large vessel occlusion nested in the population-based registry of stroke code activations in Catalonia from January 2017 to June 2019. The effect of MT on good functional outcome (modified Rankin Score ≤2) and survival at 3 months was studied using inverse probability of treatment weighting (IPTW) analysis in three pre-defined baseline prognostic groups: poor (if pre-stroke disability, age >85 years, N2021-01-01T00:00:00Z2021 Sep2026-05-08T16:08:26.236Z2025-02-18T23:55:26.419ZS-EPMC85212603464938410.5853/jos.2021.00962