{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(6)"],"submitter":["Honda C"],"pubmed_abstract":["Tumor-infiltrating lymphocytes (TILs) are a significant prognostic factor in triple-negative breast cancer. However, the clinicopathological significance of TILs in estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer remains unclear. The purpose of the present study was to evaluate the role of TILs in the prognosis of ER-positive and HER2-negative breast cancer. A total of 65 consecutive patients with ER-positive and HER2-negative breast cancer were examined. TILs in stromal tissue (str-TILs) were graded using the International TILs Working Group criteria. The association between several clinicopathological factors and TIL grade were investigated, and the prognostic impact of TILs was compared between luminal A-like and luminal B-like "],"journal":["Molecular and clinical oncology"],"pagination":["252"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8521382"],"repository":["biostudies-literature"],"pubmed_title":["Prognostic value of tumor-infiltrating lymphocytes in estrogen receptor-positive and human epidermal growth factor receptor 2-negative breast cancer."],"pmcid":["PMC8521382"],"pubmed_authors":["Honda C","Kurozumi S","Horiguchi J","Yajima R","Masuda K","Fujii T","Oyama T","Shirabe K","Nakazawa Y","Ogino M","Hanna-Khalil B","Makiguchi T","Obayashi S","Katayama A"],"additional_accession":[]},"is_claimable":false,"name":"Prognostic value of tumor-infiltrating lymphocytes in estrogen receptor-positive and human epidermal growth factor receptor 2-negative breast cancer.","description":"Tumor-infiltrating lymphocytes (TILs) are a significant prognostic factor in triple-negative breast cancer. However, the clinicopathological significance of TILs in estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer remains unclear. The purpose of the present study was to evaluate the role of TILs in the prognosis of ER-positive and HER2-negative breast cancer. A total of 65 consecutive patients with ER-positive and HER2-negative breast cancer were examined. TILs in stromal tissue (str-TILs) were graded using the International TILs Working Group criteria. The association between several clinicopathological factors and TIL grade were investigated, and the prognostic impact of TILs was compared between luminal A-like and luminal B-like ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-04T10:55:15.233Z","creation":"2025-04-04T10:55:15.233Z"},"accession":"S-EPMC8521382","cross_references":{"pubmed":["34671471"],"doi":["10.3892/mco.2021.2414"]}}