{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(10)"],"submitter":["Bai G"],"pubmed_abstract":["The ring strain present in azetidines can lead to undesired stability issues. Herein, we described a series of N-substituted azetidines which undergo an acid-mediated intramolecular ring-opening decomposition via nucleophilic attack of a pendant amide group. Studies were conducted to understand the decomposition mechanism enabling the design of stable analogues."],"journal":["ACS medicinal chemistry letters"],"pagination":["1585-1588"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8521649"],"repository":["biostudies-literature"],"pubmed_title":["Intramolecular Ring-Opening Decomposition of Aryl Azetidines."],"pmcid":["PMC8521649"],"pubmed_authors":["O'Connell TN","Brodney MA","Ogilvie K","Yan J","Li C","Salomon-Ferrer R","LaChapelle EA","Philippe L","McAllister LA","Czabaniuk LC","Shapiro MJ","Butler CR","Gilbert AM","Bai G","Uccello DP","Brown MF","Starr JT","Withka JM"],"additional_accession":[]},"is_claimable":false,"name":"Intramolecular Ring-Opening Decomposition of Aryl Azetidines.","description":"The ring strain present in azetidines can lead to undesired stability issues. Herein, we described a series of N-substituted azetidines which undergo an acid-mediated intramolecular ring-opening decomposition via nucleophilic attack of a pendant amide group. Studies were conducted to understand the decomposition mechanism enabling the design of stable analogues.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-04T21:42:06.666Z","creation":"2025-04-04T21:42:06.666Z"},"accession":"S-EPMC8521649","cross_references":{"pubmed":["34676040"],"doi":["10.1021/acsmedchemlett.1c00402"]}}