biostudies-literaturePetersen MRCenters for Disease Control and PreventionDivision of Intramural Research, National Institute of Allergy and Infectious DiseasesNCEZID CDC HHSofab409https://www.ebi.ac.uk/biostudies/studies/S-EPMC8522265biostudies-literatureUnknown8(9)Data from the National Inpatient Sample indicate that <i>Clostridioides difficile</i> prevalence decreased from 10.1 (95% confidence interval [CI] = 9.9-10.3) to 8.6 (95% CI = 8.5-8.8) per 1000 hospital discharges between 2016 and 2018, after accounting for age, sex, and race. There was heterogeneity in the prevalence and decrease in prevalence by geographic region in the United States.Open forum infectious diseases<i>Clostridioides difficile</i> Prevalence in the United States: National Inpatient Sample, 2016 to 2018.PMC8522265R01AI128779U01 CK000589U01CK000589T32AI102623R01AI120938Cosgrove SEKlein EYPetersen MRZhu XPatel EUTobian AARGrabowski MKQuinn TCfalse<i>Clostridioides difficile</i> Prevalence in the United States: National Inpatient Sample, 2016 to 2018.Data from the National Inpatient Sample indicate that <i>Clostridioides difficile</i> prevalence decreased from 10.1 (95% confidence interval [CI] = 9.9-10.3) to 8.6 (95% CI = 8.5-8.8) per 1000 hospital discharges between 2016 and 2018, after accounting for age, sex, and race. There was heterogeneity in the prevalence and decrease in prevalence by geographic region in the United States.2021-01-01T00:00:00Z2021 Sep2025-04-21T14:54:02.899Z2025-04-21T14:54:02.899ZS-EPMC85222653467169410.1093/ofid/ofab409