biostudies-literatureSnyman JSub-Saharan African Network for TB/HIV Research Excellence, a DELTASAfrica Health Research InstituteSouth African Department of Science and Innovation through the National Research Foundation (South African Research Chairs InitiativeBill and Melinda Gates FoundationWellcome TrustAfrica Initiativee249-e256https://www.ebi.ac.uk/biostudies/studies/S-EPMC8522359biostudies-literatureUnknown75(1)<h4>Background</h4>There is limited understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis in African populations with a high burden of infectious disease comorbidities such as human immunodeficiency virus (HIV). The kinetics, magnitude, and duration of virus-specific antibodies and B-cell responses in people living with HIV (PLWH) in sub-Saharan Africa have not been fully characterized.<h4>Methods</h4>We longitudinally followed SARS-CoV-2-infected individuals in Durban, KwaZulu-Natal, South Africa, and characterized SARS-CoV-2 receptor-binding domain-specific immunoglobulin (Ig) M, IgG, and IgA weekly for 1 month and at 3 months post-diagnosis. Thirty of 72 (41.7%) were PLWH, 25/30 (83%) of whom were on antiretroviral therapy (ART) with full HIV suppresClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaSimilar Antibody Responses Against Severe Acute Respiratory Syndrome Coronavirus 2 in Individuals Living Without and With Human Immunodeficiency Virus on Antiretroviral Therapy During the First South African Infection Wave.PMC8522359INV-01894464809201433/Z/16/ZDEL-15–006107752/Z/15/ZNaidoo KNdung'u THarling GSmit TGoulder PMadansein RCOVID-19 Mechanisms and Multi-omics at the Intersection of TB and HIV in KwaZulu-Natal (COMMIT-KZN Team)Wong EKrause RHerbst KSigal AGanga YMoshabela MLeslie AJeena PNyamande KSteyn AMazibuko MKlein NDullabh KJMthabela NPatel VArchary MKhoza THarrichandparsad RSnyman JReddy TKloverpris HHwa SHKarim FMarakalala MNdhlovu ZMuema DPadayatchi NfalseSimilar Antibody Responses Against Severe Acute Respiratory Syndrome Coronavirus 2 in Individuals Living Without and With Human Immunodeficiency Virus on Antiretroviral Therapy During the First South African Infection Wave.<h4>Background</h4>There is limited understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis in African populations with a high burden of infectious disease comorbidities such as human immunodeficiency virus (HIV). The kinetics, magnitude, and duration of virus-specific antibodies and B-cell responses in people living with HIV (PLWH) in sub-Saharan Africa have not been fully characterized.<h4>Methods</h4>We longitudinally followed SARS-CoV-2-infected individuals in Durban, KwaZulu-Natal, South Africa, and characterized SARS-CoV-2 receptor-binding domain-specific immunoglobulin (Ig) M, IgG, and IgA weekly for 1 month and at 3 months post-diagnosis. Thirty of 72 (41.7%) were PLWH, 25/30 (83%) of whom were on antiretroviral therapy (ART) with full HIV suppres2022-01-01T00:00:00Z2022 Aug2026-05-09T09:34:45.676Z2024-12-03T19:27:36.388ZS-EPMC85223593447258310.1093/cid/ciab758