biostudies-literatureUnknown65(11)Zaidan NExtremely drug-resistant (XDR) Acinetobacter baumannii causes challenging nosocomial infections. We report the case of a patient with XDR A. baumannii pneumonia and septic shock successfully treated with cefiderocol and a novel antibiotic obtained via expanded access protocol. With focused research and drug development efforts, the poor outcomes associated with these infections may be mitigated.Antimicrobial agents and chemotherapye0092421https://www.ebi.ac.uk/biostudies/studies/S-EPMC8522738biostudies-literatureExtensively Drug-Resistant Acinetobacter baumannii Nosocomial Pneumonia Successfully Treated with a Novel Antibiotic Combination.PMC8522738Zaidan NHornak JPReynoso DfalseExtensively Drug-Resistant Acinetobacter baumannii Nosocomial Pneumonia Successfully Treated with a Novel Antibiotic Combination.Extremely drug-resistant (XDR) Acinetobacter baumannii causes challenging nosocomial infections. We report the case of a patient with XDR A. baumannii pneumonia and septic shock successfully treated with cefiderocol and a novel antibiotic obtained via expanded access protocol. With focused research and drug development efforts, the poor outcomes associated with these infections may be mitigated.2021-01-01T00:00:00Z2021 Oct2025-04-19T12:12:41.451Z2025-04-19T12:12:41.451ZS-EPMC85227383437057610.1128/AAC.00924-2110.1128/aac.00924-21