biostudies-literatureUnknown35(11)Persiani RUniversità Cattolica del Sacro Cuore<h4>Background</h4>Transanal total mesorectal excision (TaTME) was introduced in 2009 as a dedicated approach for the treatment of mid-low rectal cancer. We aimed to describe and discuss the learning curve for 121 consecutive TaTME procedures performed by the same team.<h4>Methods</h4>The primary outcome was the number of operations required to decrease the mean operative time (mOT). The secondary outcomes were the number of operations required to decrease the major complication (MC) rate, the anastomotic leakage (AL) rate, the clinical anastomotic failure rate, and the reoperation rate. A cumulative sum (CUSUM) curve analysis was used to identify the inflection points. As an integrative analysis, Bernoulli CUSUM curves, risk-adjusted CUSUM curves based on the observed-expected outcomes, aSurgical endoscopy6190-6200https://www.ebi.ac.uk/biostudies/studies/S-EPMC8523384biostudies-literatureThe learning curve of TaTME for mid-low rectal cancer: a comprehensive analysis from a five-year institutional experience.PMC8523384Belia FAgnes APersiani RD'Ugo DBiondi AfalseThe learning curve of TaTME for mid-low rectal cancer: a comprehensive analysis from a five-year institutional experience.<h4>Background</h4>Transanal total mesorectal excision (TaTME) was introduced in 2009 as a dedicated approach for the treatment of mid-low rectal cancer. We aimed to describe and discuss the learning curve for 121 consecutive TaTME procedures performed by the same team.<h4>Methods</h4>The primary outcome was the number of operations required to decrease the mean operative time (mOT). The secondary outcomes were the number of operations required to decrease the major complication (MC) rate, the anastomotic leakage (AL) rate, the clinical anastomotic failure rate, and the reoperation rate. A cumulative sum (CUSUM) curve analysis was used to identify the inflection points. As an integrative analysis, Bernoulli CUSUM curves, risk-adjusted CUSUM curves based on the observed-expected outcomes, a2021-01-01T00:00:00Z2021 Nov2025-04-20T02:02:03.141Z2025-04-20T02:02:03.141ZS-EPMC85233843310688710.1007/s00464-020-08115-0