{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Schmidt M"],"funding":["Deutsche Forschungsgemeinschaft","Deutsche Krebshilfe"],"pubmed_abstract":["Myogenic differentiation, muscle stem cell functionality, and regeneration of skeletal muscle are cellular processes under tight control of various signaling pathways. Here, we investigated the role of non-canonical NF-κB signaling in myogenic differentiation, muscle stem cell functionality, and regeneration of skeletal muscle. We stimulated non-canonical NF-κB signaling with an agonistically acting antibody of the lymphotoxin beta receptor (LTβR). Interestingly, we found that stimulation of non-canonical NF-κB signaling through the LTβR agonist impairs myogenic differentiation, muscle stem cell function, and regeneration of skeletal muscle. Furthermore, we show that stimulation of non-canonical NF-κB signaling by the LTβR agonist coincides with activation of canonical NF-κB signaling. We "],"journal":["Frontiers in cell and developmental biology"],"pagination":["721543"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8523804"],"repository":["biostudies-literature"],"pubmed_title":["Stimulation of Non-canonical NF-κB Through Lymphotoxin-β-Receptor Impairs Myogenic Differentiation and Regeneration of Skeletal Muscle."],"pmcid":["PMC8523804"],"pubmed_authors":["Bigot A","Schmidt M","Poser C","Weidemann A","von Maltzahn J"],"additional_accession":[]},"is_claimable":false,"name":"Stimulation of Non-canonical NF-κB Through Lymphotoxin-β-Receptor Impairs Myogenic Differentiation and Regeneration of Skeletal Muscle.","description":"Myogenic differentiation, muscle stem cell functionality, and regeneration of skeletal muscle are cellular processes under tight control of various signaling pathways. Here, we investigated the role of non-canonical NF-κB signaling in myogenic differentiation, muscle stem cell functionality, and regeneration of skeletal muscle. We stimulated non-canonical NF-κB signaling with an agonistically acting antibody of the lymphotoxin beta receptor (LTβR). Interestingly, we found that stimulation of non-canonical NF-κB signaling through the LTβR agonist impairs myogenic differentiation, muscle stem cell function, and regeneration of skeletal muscle. Furthermore, we show that stimulation of non-canonical NF-κB signaling by the LTβR agonist coincides with activation of canonical NF-κB signaling. We ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-08-16T03:05:30.342Z","creation":"2025-04-20T02:02:11.511Z"},"accession":"S-EPMC8523804","cross_references":{"pubmed":["34676210"],"doi":["10.3389/fcell.2021.721543"]}}