{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chalak LF"],"funding":["NICHD NIH HHS","NCATS NIH HHS"],"pagination":["1484-1493"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8524352"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["78(12)"],"pubmed_abstract":["<h4>Importance</h4>Compared with normothermia, hypothermia has been shown to reduce death or disability in neonatal hypoxic ischemic encephalopathy but data on seizures during rewarming and associated outcomes are scarce.<h4>Objective</h4>To determine whether electrographic seizures are more likely to occur during rewarming compared with the preceding period and whether they are associated with abnormal outcomes in asphyxiated neonates receiving hypothermia therapy.<h4>Design, setting, and participants</h4>This prespecified nested cohort study of infants enrolled in the Optimizing Cooling (OC) multicenter Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network trial from December 2011 to December 2013 with 2 years' follow-up randomi"],"journal":["JAMA neurology"],"pubmed_title":["Association Between Increased Seizures During Rewarming After Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy and Abnormal Neurodevelopmental Outcomes at 2-Year Follow-up: A Nested Multisite Cohort Study."],"pmcid":["PMC8524352"],"funding_grant_id":["UG1 HD027904","UG1 HD068278","UL1 TR000042","UG1 HD068263","UG1 HD053109","UL1 TR000077","UL1 TR003167","U24 HD095254","UG1 HD053089","UG1 HD034216","UG1 HD040689","U10 HD021373","UG1 HD027851","UG1 HD027880","UG1 HD087226","U10 HD040689"],"pubmed_authors":["Huffman LC","Panaitescu B","Petrie Huitema CM","Grisby C","Grimes S","Hartenberger CH","Johnson ME","Williams A","Hart B","Herron DE","Schibler K","Timan CJ","Twell Boatman C","Goldstein RF","Wineski L","Shah BA","Jones ME","Watterberg KL","Ambalavanan N","Cotten CM","Burke RT","Lakshminrusimha S","Rabe GK","Slaughter JL","Walsh MC","Tyson JE","Miller LC","Dion Nist M","Goldberg RN","Bapat R","Holmes AM","Ball MB","Peralta-Carcelen M","Harmon HM","Pappas A","Taylor HL","Jensen RL","Ramon E","Zaghoul N","Johnson KJ","Guzman A","Nelin LD","Papile LA","Stein M","Farooq O","Bartman T","Keim SA","Luzader P","Segar JL","Christensen MK","Walker JR","Cosby SS","Abbasi S","McElroy SJ","Gulati I","Bajaj M","DeBattista AM","Lowe JR","Rodgers E","Wolfe T","Purdy IB","Knoll AM","Weiss HE","Little E","VonLehmden AM","De Jesus LC","McGowan EC","Stoll BJ","Newman JE","Warner DD","Seabrook R","Truog WE","Sanchez PJ","Proud MS","Fisher KA","Polin RA","Adams SS","Carlo WA","DeMauro SB","Clifford B","Finkle J","Fowler A","Gustafson KE","Gutentag J","Guilford S","Adams-Chapman Deceased I","Madden LA","Van Meurs KP","Chen L","Stork EK","Hague CD","Pallotto EK","McDonald SA","Yost K","Clark CL","Prentice JE","Chicoine LG","Wallace D","Sacilowski MG","Bernhardt J","Hines AC","Stevenson DK","Wynn K","Johnson K","Guillet R","Higgins RD","Brumbaugh JE","Scott A","Myers GJ","Natarajan G","Dagle JM","Reynolds AM","Kirpalani H","Sullivan RA","Backstrom Lacy C","Eastman DL","Kilbride HW","Sharp T","Loggins YC","Chao M","Heyne ET","Sommers R","Keszler M","Bhavsar V","Randolph DA","Bann CM","Horihan CA","Pedroza C","Wilson Archer S","Mancini T","Ashley PL","Newman NS","Smiley LC","Poindexter BB","Patel RM","Brion LP","Siner BS","Hamrick SEG","Hibbs AM","Joyce J","Sabaratnam P","Conway P","Jadcherla SR","Hurt H","Hokenson M","Zaterka-Baxter KM","Richard L","Dysart KC","Carter SL","Wiggins SA","Alksninis B","Wereszczak JK","Heyne RJ","Geller R","Lytle C","Sood BG","Malcolm WF","Grothause JL","Cucinotta DM","Parikh NA","Laptook AR","Scorsone AM","Lindower JB","Lucash RE","Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network","Vohr BR","Colaizy TT","Sokol GM","Lee LE","Crawford MM","Shepherd EG","Wilson LD","Caskey M","Hale EC","O'Donnell Auman J","Chanlaw T","D'Angio CT","Collins MV","Bernbaum JC","Bottcher DI","Devaskar U","Barks J","Widness JA","Zadell A","Bell EF","Hinz Woldt E","Davis AS","Pickett JW","Moorehead P","Caplan MS","Gauldin C","Carlton DP","Binion K","Yeates KO","Wyckoff MH","Schmidt B","Vasil DM","Krueger CE","Gerdes M","Hensman AM","Murphy CR","Guerina N","Fortney CA","Roghair RD","Fearns E","Mackie C","Vieira E","Laroira N","Childs K","Garg M","Ulloa JA","Bara R","Haines K","Nelin MA","Ellsbury DL","Carey H","Yossef-Salameh L","Aliaga S","Chalak LF","Ohls RK","Chock VY","Tan S","McGregor S","Shankaran S","Gantz MG","Wadkins HIM","Gunn S","Laughon MM","Acarregui MJ","Wispe J","Keszler ML","Oh W","Merzbach J","Sundquist Beauman S","Chawla S","Bose CL","Chaudhary AS","Duncan AF","Maitre NL","DeAnda ME","Minnich HM","Klein JM","Bonachea E","Gabrio J","Das A","Phillips VA","Fuller J"],"additional_accession":[]},"is_claimable":false,"name":"Association Between Increased Seizures During Rewarming After Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy and Abnormal Neurodevelopmental Outcomes at 2-Year Follow-up: A Nested Multisite Cohort Study.","description":"<h4>Importance</h4>Compared with normothermia, hypothermia has been shown to reduce death or disability in neonatal hypoxic ischemic encephalopathy but data on seizures during rewarming and associated outcomes are scarce.<h4>Objective</h4>To determine whether electrographic seizures are more likely to occur during rewarming compared with the preceding period and whether they are associated with abnormal outcomes in asphyxiated neonates receiving hypothermia therapy.<h4>Design, setting, and participants</h4>This prespecified nested cohort study of infants enrolled in the Optimizing Cooling (OC) multicenter Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network trial from December 2011 to December 2013 with 2 years' follow-up randomi","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-05-08T11:29:12.705Z","creation":"2025-04-19T09:54:01.902Z"},"accession":"S-EPMC8524352","cross_references":{"pubmed":["34882200"],"doi":["10.1001/jamaneurol.2021.3723"]}}