{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ripenko V"],"funding":["European Research Council"],"pagination":["14061-14068"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8524415"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["86(20)"],"pubmed_abstract":["<i>In flow</i> photochemical addition of propellane to diacetyl allowed construction of the bicyclo[1.1.1]pentane (BCP) core in a 1 kg scale within 1 day. Haloform reaction of the formed diketone in batch afforded bicyclo[1.1.1]pentane-1,3-dicarboxylic acid in a multigram amount. Representative gram scale transformations of the diacid were also performed to obtain various BCP-containing building blocks-alcohols, acids, amines, trifluoroborates, amino acids, <i>etc</i>.-for medicinal chemistry."],"journal":["The Journal of organic chemistry"],"pubmed_title":["Large-Scale Synthesis and Modifications of Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid (BCP)."],"pmcid":["PMC8524415"],"funding_grant_id":["101000893","101000893 - BENOVELTY"],"pubmed_authors":["Klymov I","Mykhailiuk PK","Zhersh S","Ripenko V","Vysochyn D"],"additional_accession":[]},"is_claimable":false,"name":"Large-Scale Synthesis and Modifications of Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid (BCP).","description":"<i>In flow</i> photochemical addition of propellane to diacetyl allowed construction of the bicyclo[1.1.1]pentane (BCP) core in a 1 kg scale within 1 day. Haloform reaction of the formed diketone in batch afforded bicyclo[1.1.1]pentane-1,3-dicarboxylic acid in a multigram amount. Representative gram scale transformations of the diacid were also performed to obtain various BCP-containing building blocks-alcohols, acids, amines, trifluoroborates, amino acids, <i>etc</i>.-for medicinal chemistry.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-21T14:52:24.829Z","creation":"2024-11-19T19:07:47.554Z"},"accession":"S-EPMC8524415","cross_references":{"pubmed":["34166594"],"doi":["10.1021/acs.joc.1c00977"]}}